| Drug General Information |
| Drug ID |
DX1Z5O
|
| Drug Name |
5-(5-((4-(2-(dimethylamino)ethyl)piperazin-1-yl)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile
|
| Synonyms |
CHEMBL569822
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C32H35N7O
|
| Canonical SMILES |
CN(C)CCN1CCN(Cc2ccc3oc(cc3c2)c4cncc(C#N)c4Nc5ccc6[nH]ccc6c5C)CC1
|
| InChI |
InChI=1S/C32H35N7O/c1-22-26-8-9-35-29(26)6-5-28(22)36-32-25(18-33)19-34-20-27(32)31-17-24-16-23(4-7-30(24)40-31)21-39-14-12-38(13-15-39)11-10-37(2)3/h4-9,16-17,19-20,35H,10-15,21H2,1-3H3,(H,34,36)
|
| InChIKey |
HDYPWSDXJZTYPP-UHFFFAOYSA-N
|
| Target and Pathway |
| Target(s) |
Protein kinase C, delta type |
Target Info |
|
[1]
|
|---|
| Protein kinase C, theta type |
Target Info |
|
[1]
|
|
KEGG Pathway
|
Chemokine signaling pathway
|
|
Vascular smooth muscle contraction
|
|
Tight junction
|
|
Fc epsilon RI signaling pathway
|
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Fc gamma R-mediated phagocytosis
|
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Neurotrophin signaling pathway
|
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Inflammatory mediator regulation of TRP channels
|
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GnRH signaling pathway
|
|
Estrogen signaling pathway
|
|
Type II diabetes mellitushsa04064:NF-kappa B signaling pathway
|
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T cell receptor signaling pathway
|
|
Adipocytokine signaling pathway
|
|
Measles
|
|
NetPath Pathway
|
IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathway
|
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Alzheimer disease-amyloid secretase pathway
|
|
Angiogenesis
|
|
Apoptosis signaling pathway
|
|
B cell activation
|
|
EGF receptor signaling pathway
|
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Endothelin signaling pathway
|
|
FGF signaling pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
VEGF signaling pathway
|
|
Wnt signaling pathway
|
|
5HT2 type receptor mediated signaling pathway
|
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Histamine H1 receptor mediated signaling pathway
|
|
Oxytocin receptor mediated signaling pathway
|
|
Thyrotropin-releasing hormone receptor signaling pathway
|
|
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
|
|
T cell activation
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
Endothelins
|
|
LPA receptor mediated events
|
|
Thromboxane A2 receptor signaling
|
|
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
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IGF1 pathway
|
|
Ceramide signaling pathway
|
|
IFN-gamma pathway
|
|
ErbB1 downstream signaling
|
|
Syndecan-4-mediated signaling events
|
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IL6-mediated signaling events
|
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PDGFR-beta signaling pathway
|
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Hedgehog signaling events mediated by Gli proteins
|
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Signaling events mediated by VEGFR1 and VEGFR2
|
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PAR1-mediated thrombin signaling events
|
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Syndecan-2-mediated signaling events
|
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Validated transcriptional targets of TAp63 isoforms
|
|
p53 pathway
|
|
Trk receptor signaling mediated by the MAPK pathway
|
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Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
Alpha-synuclein signalingendothelinpathway:Endothelins
|
|
TCR signaling in naï
|
|
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
|
TCR signaling in naï
|
|
Downstream signaling in naï
|
|
Reactome
|
Apoptotic cleavage of cellular proteins
|
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Calmodulin induced events
|
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Effects of PIP2 hydrolysis
|
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DAG and IP3 signaling
|
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Role of phospholipids in phagocytosis
|
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G alpha (z) signalling events
|
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HuR (ELAVL1) binds and stabilizes mRNA
|
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VEGFR2 mediated cell proliferation
|
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CLEC7A (Dectin-1) signaling
|
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Interferon gamma signalingR-HSA-111465:Apoptotic cleavage of cellular proteins
|
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Inactivation, recovery and regulation of the phototransduction cascade
|
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FCERI mediated NF-kB activation
|
|
WikiPathways
|
TCR Signaling Pathway
|
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Type II interferon signaling (IFNG)
|
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Calcium Regulation in the Cardiac Cell
|
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Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
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Wnt Signaling Pathway
|
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Wnt Signaling Pathway and Pluripotency
|
|
MAPK Signaling Pathway
|
|
IL-6 signaling pathway
|
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G Protein Signaling Pathways
|
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Myometrial Relaxation and Contraction Pathways
|
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Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
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DAG and IP3 signaling
|
|
Alpha 6 Beta 4 signaling pathway
|
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BDNF signaling pathway
|
|
Oncostatin M Signaling Pathway
|
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Corticotropin-releasing hormone
|
|
AGE/RAGE pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Signaling Pathways in Glioblastoma
|
|
miRs in Muscle Cell Differentiation
|
|
Opioid Signalling
|
|
GPCR downstream signaling
|
|
Effects of PIP2 hydrolysis
|
|
Apoptotic execution phase
|
|
Type II diabetes mellitusWP69:TCR Signaling Pathway
|
|
Fc epsilon receptor (FCERI) signaling
|
|
TCR signaling
|
|
Netrin-1 signaling
|
| References |
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |
|---|
