Drug Information

Drug General Information
Drug ID
DX1YVK
Drug Name
N-(4-{4-[2-({[2-(Dimethylamino)ethyl]amino}methyl)-1Hpyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl}phenyl)-N'-phenylurea
Synonyms
CHEMBL1096491
Indication Discovery agent Investigative [1587926]
Formula
C30H34N8O
Canonical SMILES
CCn1cc(c2ccnc3[nH]c(CNCCN(C)C)cc23)c(n1)c4ccc(NC(=O)Nc5ccccc5)cc4
InChI
InChI=1S/C30H34N8O/c1-4-38-20-27(25-14-15-32-29-26(25)18-24(33-29)19-31-16-17-37(2)3)28(36-38)21-10-12-23(13-11-21)35-30(39)34-22-8-6-5-7-9-22/h5-15,18,20,31H,4,16-17,19H2,1-3H3,(H,32,33)(H2,34,35,39)
InChIKey
DQJRSRINKOLTGU-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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