Drug Information

Drug General Information
Drug ID
DX1YFV
Drug Name
Oxo-[2-((E)-2-phenyl-ethenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-acetic acid
Synonyms
CHEMBL140335
Indication Discovery agent Investigative [1587926]
Formula
C19H17NO5S
Canonical SMILES
OC(=O)C(=O)C1Cc2ccccc2CN1S(=O)(=O)\\C=C\\c3ccccc3
InChI
InChI=1S/C19H17NO5S/c21-18(19(22)23)17-12-15-8-4-5-9-16(15)13-20(17)26(24,25)11-10-14-6-2-1-3-7-14/h1-11,17H,12-13H2,(H,22,23)/b11-10+
InChIKey
GIKKFOVDJPQBSW-ZHACJKMWSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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