Drug Information

Drug General Information
Drug ID
DX1WFY
Drug Name
N-(pyridin-2-ylmethyl)-6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-amine
Synonyms
CHEMBL1093879
Indication Discovery agent Investigative [1587926]
Formula
C25H25N5
Canonical SMILES
C(Nc1cc2c(\\C=C\\c3ccccc3)n[nH]c2cc1N4CCCC4)c5ccccn5
InChI
InChI=1S/C25H25N5/c1-2-8-19(9-3-1)11-12-22-21-16-24(27-18-20-10-4-5-13-26-20)25(17-23(21)29-28-22)30-14-6-7-15-30/h1-5,8-13,16-17,27H,6-7,14-15,18H2,(H,28,29)/b12-11+
InChIKey
AIQJXTOEZSDXHV-VAWYXSNFSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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