Drug Information

Drug General Information
Drug ID
DX1SOS
Drug Name
(R)-2-(4-Methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL291758
Indication Discovery agent Investigative [1587926]
Formula
C19H19N3O5S
Canonical SMILES
COc1ccc(cc1)S(=O)(=O)N2Cc3[nH]c4ccccc4c3C[C@@H]2C(=O)NO
InChI
InChI=1S/C19H19N3O5S/c1-27-12-6-8-13(9-7-12)28(25,26)22-11-17-15(10-18(22)19(23)21-24)14-4-2-3-5-16(14)20-17/h2-9,18,20,24H,10-11H2,1H3,(H,21,23)/t18-/m1/s1
InChIKey
FKBDRAKAEJZJEQ-GOSISDBHSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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