Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX1ADC
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| Drug Name |
methyl (6-(4-(2-(2-fluoro-5-(trifluoromethyl)phenylamino)-2-oxoethyl)phenoxy)-1H-benzoimidazol-2-yl)carbamate
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| Synonyms |
CHEMBL244288
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C24H18F4N4O4
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| Canonical SMILES |
COC(=O)Nc1nc2ccc(Oc3ccc(CC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
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| InChI |
InChI=1S/C24H18F4N4O4/c1-35-23(34)32-22-30-18-9-7-16(12-20(18)31-22)36-15-5-2-13(3-6-15)10-21(33)29-19-11-14(24(26,27)28)4-8-17(19)25/h2-9,11-12H,10H2,1H3,(H,29,33)(H2,30,31,32,34)
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| InChIKey |
KCJAPLFLYYZXFD-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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