Drug Information

Drug General Information
Drug ID
D0O5NK
Former ID
DAP000714
Drug Name
Oseltamivir
Synonyms
Agucort; Oseltamivirum; Tamvir; GS 4104; GS4104; Agucort (TN); GS-4104; Oseltamivir (INN); Oseltamivir [INN:BAN]; Ro-640796; Tamiflu (TN); Tamiflu-Free; Ro-64-0796; Tamiflu (*Phosphate salt 1:1*); Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate; Ethyl (5S,3R,4R)-4-(acetylamino)-5-amino-3-(ethylpropoxy)cyclohex-1-enecarboxylate; Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate; Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate; (-)-oseltamivir; (3R,4R,5S)-4-Acetylamino-5-amino-3-(1-ethyl-propoxy)-cyclohex-1-enecarboxylic acid; (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylic acid; 4-Acetylamino-5-amino-3-(1-ethyl-propoxy)-cyclohex-1-enecarboxylic acid; OTV
Drug Type
Small molecular drug
Indication Influenza virus [ICD10:J11.1] Approved [536361]
Therapeutic Class
Antiviral Agents
Company
Hoffmann-La Roche pharmaceutical company
Structure
Download
2D MOL

3D MOL
Formula
C16H28N2O4
Canonical SMILES
CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC
InChI
1S/C16H28N2O4/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19/h9,12-15H,5-8,17H2,1-4H3,(H,18,19)/t13-,14+,15+/m0/s1
InChIKey
VSZGPKBBMSAYNT-RRFJBIMHSA-N
CAS Number
CAS 204255-11-8
PubChem Compound ID
65028
PubChem Substance ID
10292, 626306, 7980209, 8034664, 8189453, 14825762, 14898934, 43121870, 46507602, 49958481, 50123365, 53789667, 57315247, 58106749, 75193389, 85789649, 92309047, 93166584, 96024993, 103375662, 104332669, 117576917, 118048381, 124893596, 126657793, 126681234, 126733879, 134338002, 135023115, 135811666, 137002940, 137236650, 140589553, 151982861, 152099920, 152258534, 160647368, 160963546, 164786722, 164831566, 165702338, 174006818, 175267600, 176484257, 179116828, 184546341, 185976796, 196109901, 211535901, 223556618
ChEBI ID
ChEBI:7799
SuperDrug ATC ID
J05AH02
SuperDrug CAS ID
cas=196618130
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Neuraminidase Target Info Inhibitor [535258], [536654]
KEGG Pathway Other glycan degradation
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 535258Antiviral agents for influenza, hepatitis C and herpesvirus, enterovirus and rhinovirus infections. Med J Aust. 2001 Jul 16;175(2):112-6.
Ref 536654Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102. Epub 2008 Feb 4.

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