| Target General Information |
| Target ID |
T91001
|
| Target Name |
Bacterial Elongation factor Tu (EF-Tu) |
| Gene Name |
EF-Tu |
| Species |
Peptoclostridium difficile |
| UniProt ID |
EFTU_PEPD6 |
| Sequence |
MAKAKYERTKPHVNIGTIGHVDHGKTTLTAAITKTLYDRYQLGEAVDFANIDKAPEERER
GITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSATDGPMPQTREH
ILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLTEYDFPGDDTPIVRGSALMAL
EDPKSEWGDKIVELFEQIDEYIPAPERDTDKPFLMPVEDVFSITGRGTVATGRVERGVLK
VQDEVELVGLTEAPRKVVVTGVEMFRKLLDQAQAGDNIGALLRGVQRNEIERGQVLAKTG
SVKAHTKFTAEVYVLKKEEGGRHTPFFDGYRPQFYFRTTDVTGACKLPEGIEMVMPGDNV
TMEVDLINSIVVEEGLRFSIREGGRTVASGVVATIIE [Peptoclostridium diff
icile]
|
| Drug and Corresponding Resistance Mutations |
| Mutation Info |
Missense: A376S |
| Drugs |
| Drug Name |
Kirromycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: A376V |
| Drugs |
| Drug Name |
Kirromycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: E379K |
| Drugs |
| Drug Name |
Kirromycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: G261E |
| Drugs |
| Drug Name |
Elfamycin |
Drug Info
|
[1] |
| Targeted Disease |
Enterocolitis Due To Clostridium Difficile |
|
| Mutation Info |
Missense: G317D |
| Drugs |
| Drug Name |
Kirromycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: L121Q |
| Drugs |
| Drug Name |
Kirromycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: Q125E |
| Drugs |
| Drug Name |
Kirromycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: Q125K |
| Drugs |
| Drug Name |
Kirromycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: Q125R |
| Drugs |
| Drug Name |
Kirromycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: R231C |
| Drugs |
| Drug Name |
Pulvomycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: R231V |
| Drugs |
| Drug Name |
Pulvomycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: R234F |
| Drugs |
| Drug Name |
Pulvomycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: R234S |
| Drugs |
| Drug Name |
Pulvomycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: R334C |
| Drugs |
| Drug Name |
Pulvomycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: T335A |
| Drugs |
| Drug Name |
Pulvomycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: Y161C |
| Drugs |
| Drug Name |
Kirromycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: Y161D |
| Drugs |
| Drug Name |
Kirromycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| Mutation Info |
Missense: Y161N |
| Drugs |
| Drug Name |
Kirromycin |
Drug Info
|
[2] |
| Targeted Disease |
Bacterial infection |
|
| References |
| REF 1 |
The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57.
|
| REF 2 |
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
|
