Target General Information
Target ID T83793
Target Name HIV Negative factor (nef)
Gene Name nef
Species Human immunodeficiency virus type 1 (HIV-1)
UniProt ID NEF_HV1A2
Sequence MGGKWSKRSMGGWSAIRERMRRAEPRAEPAADGVGAVSRDLEKHGAITSSNTAATNADCA
WLEAQEEEEVGFPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYH
TQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVEPEKVEEANEGENNSLLHPMSLHGMEDA
EKEVLVWRFDSKLAFHHMARELHPEYYKDC [Human immunodeficiency virus
type 1 (HIV-1)]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: D174N
Drugs
Drug Name Triciribine Drug Info [1]
Targeted Disease HIV infection
References
REF 1 Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef.Antimicrob Agents Chemother.2010 Apr;54(4):1512-9.

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