Resistance mutation info of target
| Target General Information | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T75476 | ||||||||||||||||||||||
| Target Name | Myeloid differentiation primary response protein (MyD88) | ||||||||||||||||||||||
| Gene Name | MYD88 | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| UniProt ID | MYD88_HUMAN | ||||||||||||||||||||||
| Sequence |
MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLE IRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQ QQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIR QLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFA LSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP [Ho mo sapiens] |
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| Drug and Corresponding Resistance Mutations | |||||||||||||||||||||||
| Mutation Info | Missense: L265P | ||||||||||||||||||||||
| Drugs |
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| References | |||||||||||||||||||||||
| REF 1 | Mechanisms of ibrutinib resistance in chronic lymphocytic leukaemia and non-Hodgkin lymphoma. Br J Haematol. 2015 Aug;170(4):445-56. | ||||||||||||||||||||||
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