Target General Information
Target ID T53489
Target Name Parasitic Cytochrome b (MT-CYB)
Gene Name MT-CYB
Species Plasmodium falciparum
UniProt ID CYB_PLAFA
Sequence MNFYSINLVKAHLINYPCPLNINFLWNYGFLLGIIFFIQIITGVFLASRYTPDVSYAYYS
IQHILRELWSGWCFRYMHATGASLVFLLTYLHILRGLNYSYMYLPLSWISGLILFMIFIV
TAFVGYVLPWGQMSYWGATVITNLLSSIPVAVIWICGGYTVSDPTIKRFFVLHFILPFIG
LCIVFIHIFFLHLHGSTNPLGYDTALKIPFYPNLLSLDVKGFNNVIILFLIQSLFGIIPL
SHPDNAIVVNTYVTPSQIVPEWYFLPFYAMLKTVPSKPAGLVIVLLSLQLLFLLAEQRSL
TTIIQFKMIFGARDYSVPIIWFMCAFYALLWIGCQLPQDIFILYGRLFIVLFFCSGLFVL
VHYRRTHYDYSSQANI [Plasmodium falciparum]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: Y268S
Drugs
Drug Name Atovaquone Drug Info [1]
Targeted Disease Plasmodium Falciparum Malaria
References
REF 1 Understanding the mechanism of atovaquone drug resistance in Plasmodium falciparum cytochrome b mutation Y268S using computational methods. PLoS One. 2014 Oct 15;9(10):e110041.

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