Resistance mutation info of target
Target General Information | ||||||||||||||||||
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Target ID | T52227 | |||||||||||||||||
Target Name | Bacterial Thymidylate synthase (thyA) | |||||||||||||||||
Gene Name | thyA | |||||||||||||||||
Species | Mycobacterium tuberculosis | |||||||||||||||||
UniProt ID | TYSY_MYCTU | |||||||||||||||||
Sequence |
MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELL WFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLR TDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIAS YALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFE YTYEDIVVKNYDPHPAIKAPVAV [Mycobacterium tuberculosis] |
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Drug and Corresponding Resistance Mutations | ||||||||||||||||||
Mutation Info | Missense: R222G | |||||||||||||||||
Drugs |
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Mutation Info | Missense: T202A | |||||||||||||||||
Drugs |
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References | ||||||||||||||||||
REF 1 | The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol Microbiol. 2004 Jul;53(1):275-82. |
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