Target General Information
Target ID T52227
Target Name Bacterial Thymidylate synthase (thyA)
Gene Name thyA
Species Mycobacterium tuberculosis
UniProt ID TYSY_MYCTU
Sequence MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELL
WFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLR
TDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIAS
YALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFE
YTYEDIVVKNYDPHPAIKAPVAV [Mycobacterium tuberculosis]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: R222G
Drugs
Drug Name Aminosalicylic Acid Drug Info [1]
Targeted Disease Tuberculosis
Mutation Info Missense: T202A
Drugs
Drug Name Aminosalicylic Acid Drug Info [1]
Targeted Disease Tuberculosis
References
REF 1 The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol Microbiol. 2004 Jul;53(1):275-82.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.