Target General Information
Target ID	T40696
Target Name	Bacterial DNA topoisomerase 4 subunit A (parC)
Gene Name	parC
Species	Escherichia coli
UniProt ID	PARC_ECOLI
Sequence	MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKF KKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRY TESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDI PPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVR MRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIV PRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRR RLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILEL KLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPL QEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSN QPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDA GYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDL PQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGE RGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE [Escherichia coli]
Drug and Corresponding Resistance Mutations
Mutation Info	Missense: A85T
Drugs	Drug Name Fluoroquinolones Drug Info [1]
Mutation Info	Missense: D111H
Drugs	Drug Name Fluoroquinolones Drug Info [1]
Mutation Info	Missense: E84G
Drugs	Drug Name Fluoroquinolone Drug Info [2]
Mutation Info	Missense: E87Q
Drugs	Drug Name Fluoroquinolone Drug Info [1]
Mutation Info	Missense: E91G
Drugs	Drug Name Fluoroquinolone Drug Info [1]
Mutation Info	Missense: S129P
Drugs	Drug Name Fluoroquinolones Drug Info [1]
Mutation Info	Missense: S80I
Drugs	Drug Name Fluoroquinolone Drug Info [2]
Mutation Info	Missense: S83L
Drugs	Drug Name Fluoroquinolone Drug Info [1]
Mutation Info	Missense: S83W
Drugs	Drug Name Fluoroquinolone Drug Info [1]
	Drug Name Quinolone Drug Info [3]
Mutation Info	Missense: S84F
Drugs	Drug Name Fluoroquinolones Drug Info [2]
Mutation Info	Missense: S84P
Drugs	Drug Name Fluoroquinolone Drug Info [1]
Mutation Info	Missense: S87R
Drugs	Drug Name Fluoroquinolone Drug Info [1]
Mutation Info	Missense: W106G
Drugs	Drug Name Fluoroquinolones Drug Info [1]
References
REF 1	The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57.
REF 2	CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
REF 3	Antibacterial Resistance in Ureaplasma Species and Mycoplasma hominis Isolates from Urine Cultures in College-Aged Females. Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01104-17.

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