Resistance mutation info of target
Target General Information | ||||||||||||||||||
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Target ID | T35465 | |||||||||||||||||
Target Name | Folate transporter 1 (SLC19A1) | |||||||||||||||||
Gene Name | SLC19A1 | |||||||||||||||||
Species | Homo sapiens | |||||||||||||||||
UniProt ID | S19A1_HUMAN | |||||||||||||||||
Sequence |
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFT REQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQ LMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRV SFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGH ALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPS SIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKA AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPV TTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ [Homo sa piens] |
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Drug and Corresponding Resistance Mutations | ||||||||||||||||||
Mutation Info | Missense: S309F | |||||||||||||||||
Drugs |
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References | ||||||||||||||||||
REF 1 | Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eight... Biochem Pharmacol. 1999 Nov 15;58(10):1615-24. |
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