Resistance mutation info of target
Target General Information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Target ID | T12355 | |||||||||||||||||
Target Name | G1/S-specific cyclin D1 (CCND1) | |||||||||||||||||
Gene Name | CCND1 | |||||||||||||||||
Species | Homo sapiens | |||||||||||||||||
UniProt ID | CCND1_HUMAN | |||||||||||||||||
Sequence |
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI [Hom o sapiens] |
|||||||||||||||||
Drug and Corresponding Resistance Mutations | ||||||||||||||||||
Mutation Info | Missense: C47S | |||||||||||||||||
Drugs |
|
|||||||||||||||||
Mutation Info | Missense: T286A | |||||||||||||||||
Drugs |
|
|||||||||||||||||
Mutation Info | Missense: Y44D | |||||||||||||||||
Drugs |
|
|||||||||||||||||
References | ||||||||||||||||||
REF 1 | CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma.Oncotarget.2016 Nov 8;7(45):73558-73572. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.