Target General Information
Target ID T12355
Target Name G1/S-specific cyclin D1 (CCND1)
Gene Name CCND1
Species Homo sapiens
UniProt ID CCND1_HUMAN
Sequence MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI [Hom
o sapiens]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: C47S
Drugs
Drug Name Ibrutinib Drug Info [1]
Targeted Disease Refractory hematologic malignancy
Mutation Info Missense: T286A
Drugs
Drug Name Ibrutinib Drug Info [1]
Targeted Disease Refractory hematologic malignancy
Mutation Info Missense: Y44D
Drugs
Drug Name Ibrutinib Drug Info [1]
Targeted Disease Refractory hematologic malignancy
References
REF 1 CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma.Oncotarget.2016 Nov 8;7(45):73558-73572.

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