Target General Information
Target ID T11843
Target Name Vitamin K epoxide reductase complex subunit 1 (VKORC1)
Gene Name VKORC1
Species Homo sapiens
UniProt ID VKOR1_HUMAN
Sequence MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWG
RGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYL
AWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH [Homo sapiens]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: V66M
Drugs
Drug Name Warfarin Drug Info [1]
Targeted Disease Blood clots
Drug Name Acenocoumarol Drug Info [2]
Targeted Disease Recurrent pulmonary embolism
References
REF 1 VKORC1 V66M mutation in African Brazilian patients resistant to oral anticoagulant therapy.Thromb Res.2010 Sep;126(3):e206-10.
REF 2 [Resistance to acenocoumarol revealing a missense mutation of the vitamin K epoxyde reductase VKORC1: a case report].Ann Cardiol Angeiol (Paris).2015 Feb;64(1):59-61.

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