Resistance mutation info of target
Target General Information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Target ID | T03818 | |||||||||||||||||
Target Name | Peroxisome proliferator-activated receptor gamma (PPARG) | |||||||||||||||||
Gene Name | PPARG | |||||||||||||||||
Species | Homo sapiens | |||||||||||||||||
UniProt ID | PPARG_HUMAN | |||||||||||||||||
Sequence |
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL LQVIKKTETDMSLHPLLQEIYKDLY [Homo sapiens] |
|||||||||||||||||
Drug and Corresponding Resistance Mutations | ||||||||||||||||||
Mutation Info | Missense: P465L | |||||||||||||||||
Drugs |
|
|||||||||||||||||
Mutation Info | Missense: P467L | |||||||||||||||||
Drugs |
|
|||||||||||||||||
References | ||||||||||||||||||
REF 1 | Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.Diabetes.2010 Nov;59(11):2890-7. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.