Target General Information
Target ID T03818
Target Name Peroxisome proliferator-activated receptor gamma (PPARG)
Gene Name PPARG
Species Homo sapiens
UniProt ID PPARG_HUMAN
Sequence MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY [Homo sapiens]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: P465L
Drugs
Drug Name Insulin Drug Info [1]
Targeted Disease Coronary heart disease; Hyperglycemia and lipodystrophy ...
Mutation Info Missense: P467L
Drugs
Drug Name Insulin Drug Info [1]
Targeted Disease Coronary heart disease; Hyperglycemia and lipodystrophy ...
References
REF 1 Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.Diabetes.2010 Nov;59(11):2890-7.

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