Target Information

Target General Information

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Target ID

T99907 (Former ID: TTDI01240)

Target Name

Human immunodeficiency virus Maturation (HIV Mat)

Gene Name

NO-GeName

Target Type

Clinical trial target

[1]

Disease

[+] 1 Target-related Diseases

Human immunodeficiency virus disease [ICD-11: 1C60-1C62]

UniProt ID

NOUNIPROTAC

Drugs and Modes of Action

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Clinical Trial Drug(s)

[+] 3 Clinical Trial Drugs

BMS-955176

Drug Info

Phase 2

Human immunodeficiency virus-1 infection

[2]

GSK2838232

Drug Info

Phase 2

Human immunodeficiency virus-1 infection

[3]

GSK3640254

Drug Info

Phase 2

Human immunodeficiency virus infection

[4]

Mode of Action

[+] 2 Modes of Action

Inhibitor

[+] 2 Inhibitor drugs

BMS-955176

Drug Info

[5]

GSK3640254

Drug Info

[6]

Modulator

[+] 1 Modulator drugs

GSK2838232

Drug Info

[1]

References

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REF 1

Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037762)

REF 2

ClinicalTrials.gov (NCT02415595) Dose-finding Study of BMS-955176 to Treat HIV-1 Infected Treatment-naive Adults. U.S. National Institutes of Health.

REF 3

ClinicalTrials.gov (NCT03045861) Safety and Efficacy Study of GSK2838232 in Human Immunodeficiency Virus (HIV)-1 Infected Adults. U.S. National Institutes of Health.

REF 4

ClinicalTrials.gov (NCT03784079) A Proof of Concept Study of GSK3640254 in Human Immunodeficiency Virus-1 (HIV-1) Infected Treatment-naive Adults. U.S. National Institutes of Health.

REF 5

Clinical pipeline report, company report or official report of Bristol-Myers Squibb.

REF 6

Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next-generation HIV-1 maturation inhibitor. Pharmacol Res Perspect. 2020 Dec;8(6):e00671.

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