Target Information
| Target General Information | Top | |||||
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| Target ID |
T98315
(Former ID: TTDR01353)
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| Target Name |
SOAT2 messenger RNA (SOAT2 mRNA)
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| Synonyms |
Sterol O-acyltransferase 2 (mRNA); Cholesterol acyltransferase 2 (mRNA); Acyl-coenzyme A:cholesterol acyltransferase 2 (mRNA); ACAT2 (mRNA); ACAT-2 (mRNA); ACACT2 (mRNA)
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| Gene Name |
SOAT2
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| EC Number |
EC 2.3.1.26
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| Sequence |
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT Click to Show/Hide
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| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Target Profiles in Patients | Top | |||||
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| Target Expression Profile (TEP) | ||||||
| Target Affiliated Biological Pathways | Top | |||||
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| KEGG Pathway | [+] 1 KEGG Pathways | + | ||||
| 1 | Steroid biosynthesis | |||||
| Panther Pathway | [+] 1 Panther Pathways | + | ||||
| 1 | Androgen/estrogene/progesterone biosynthesis | |||||
| Target-Related Models and Studies | Top | |||||
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| Target Validation | ||||||
| References | Top | |||||
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| REF 1 | US patent application no. 7,202,357, Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression. | |||||
| REF 2 | Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5580-3. | |||||
| REF 3 | Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):385-8. | |||||
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