Target Information
| Target General Information | Top | |||||
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| Target ID |
T96816
(Former ID: TTDR00360)
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| Target Name |
Plasmodium Enopyruvyl shikimate phosphate synthase (Malaria ESPS)
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| Synonyms |
aroA of Aeropyrum pernix; Probable 3-phosphoshikimate 1-carboxyvinyltransferase of Aeropyrum pernix; EPSPS of Aeropyrum pernix; EPSP synthase of Aeropyrum pernix; 5-enolpyruvylshikimate-3-phosphate synthase of Aeropyrum pernix
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| Gene Name |
Malaria ESPS
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| Target Type |
Literature-reported target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Malaria [ICD-11: 1F40-1F45] | |||||
| Function |
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
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| BioChemical Class |
Alkyl aryl transferase
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| UniProt ID | ||||||
| EC Number |
EC 1.1.1.25
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| Sequence |
MCNKKCGPKCNEKYSEGGRNKGRTTNSSVEMIKHKNILSENKKRNRSDVEKYVQEEYTIS
DKFKGIIKQMINNHGTGSFEIGNVLIIVLNMKKYHDKSEKCKEFGKMLQEISISSKNELI CFADTNIMDLLHFTYHLYFKGAHGTVALHSIEVYILTSLFKTSNAKEHKRGLSEALRLAI LNDKNMFIRIKKNDLNYFVKNLKYFLNKCILNIRDIIKKGENNAKYIHVLSFGNTIGNAI KNVIKNSPGCTYINDRDYINYGIFYELKIMYELDAIDMLLLLNIEEIMIKYKLKYKLDSN FVNYYTNDIITYLHKTHSSTTNEIPLVHILNINKIQKNVLVHTPLSIIIKVFYPFICLSP FHNISTTSAQEGEFIGIVNEDRDGMIHTSTTIDMVQKKKEHTIRKINYVYLQGVGNKSEI IRVIYVSTMGRQNVRIENMNLCFDVIVFIKILKDLNFQIFLKKKKSNDIYTNVNRTVIRN CLFINGNVEQTVFLFKNFIFQKKIILNIYNSGTVCRFLLPLLCLYICKQNLKAKEEKKQL LKYIILKGDEQMESHRVINPLVNVVLKCFKYVKIKYLKKKNYLPICIYVKREIHESYTLF CSNDVAIDNYHSSQFVSSMLLISVYSETDTCIRLKFKKIHNCLNRSKKIKVKKEQKKKKI TIFRKYIKRKEVSRFKCSYYTMLSICWSCNGKKCNSINKGSTLCCKCSSSPDFNFDENYR HPRKRYNWYNFGYPINEIRNRMNSSNFSTTSKAFIDLTVRVMKLWGVRVKMKRNNYTIKK NEKYLLYSNNNDSTSIRGIAGNRSSIKSRTSNRICRSGGNKNERFNNVHYKYASMINRKH HFNDSRHILFPGIHNKKEKMLVYSLHGRGEKSSKGSCDTCKQKGVDEVKKEVHNNPHEEY NFVMLKQKEKVDQINNKEKEEDKNISNDVTNDGGYTLVKNILRYEINNDLGLYFYFIIGS LIKRQNCVIFLKLNINRMKLKNVGKGYYKIETIDFQKNVLNYFLLNILLLLGINMYINMN DEIRKIYLLTSKRMNIKKKKIIRHLEKAIRNKWKRKNGYYKKRHRNIYTTACYGVNNSTC EHLSQGECTFKYYIFEKIYMKYKIMHFRNVLLKIVVDAEYFSDDFFSICVLFCYYLLTHE RENNTELLFKIKNIHNQNIKESIRILNAVLILKICFHNILFIFCDNNSIYITKTHHQIQN CLFFKCKREHWALLCTSSDNNERKNNSSSIGSNSNNGNNNRRSRCKKKLFFNNSKYVIND DQELYLYIDAKKDHRIIFMATILSLIFKNIIIDNSYEVEKSYPHFYEQARKYLEININYV NSDNVKFHNFEEVNNYNILNEQDSKSCVEVISSSIESHESTYSCTDASRSDVDMLKNYKS PTMSTEGNYSINTRSKKLINKHTNCNSLNRPMENNTCTEKNFYKTNGAHIIHKKEANRTH RSTRGNLYFMNHEYWKTSNLNLKNVVMKKTKKCIHRKRAPKGIINLCNLTNPMLQLHTCG STGSIASEENELTVMRCGERKGIISRKGIFTVSNSGGSDSYSDSYSDSYSDSFMKCNEDP SNERSNECNKDHSNERSNGSSKWFERRGGTEEGYQTKLRLNLRERLRSGKSSSFLNKVKN QLNGDKTNLFLPSDTNYMRTYKYEEVKVNNGNVFYLLKEINNLNVHIICGIRNVGKSYLG HRIENSLVIDIDEYILNGQISFDKLTIDDFRFYEYITFVSALYLSYCLLTLKNYLWANIS GSISCNDRGDVWSNIQSSMHGNDDKKDVFLCRAENSKVCINRSCVAVHAYFDNIFFCMGN DIIFYNKKINDLYYNLKNKLLTCKNYDINSITIVLGGGIIEFYKSRQVLKKLKNVVLIKR NKRELCDICINDNVKPKLSGNIKEIINRRTVLFDELNSFHFSIPSEIKISNHIKNLKESR NKLIVSSFINFFNYKFFVKPTILDWGAIRTLSIHLKFFHSFDYELLRSSYDVVEIVYEHI GSTKDGQSEQKDGSGQRGCVEQRGCNERRCRGEELDMGGQHDQRGKNRKYAKNEEKLLAL AIFIIRSYTTKPIAVKLHTSIFHAQFFKIKNRCTKLKKDGKKNVAHLFCNNLLNVLYKYK INIVEVDIKFLKVVKYFLAHKKKKANIFFIISKHRNKVNKLKIKSDLNKLNIFHADLIKL TYNYASKSDKEFLSKTINAYNSHRLINTKLSRIKNVYNNTNEEISLYSCYVNNSFVFLYN NVTHLEYQKTNLRNLETGKNSKNIENHNYDENKKNRDFYHNNFMYGFYYQKVKSIISYVP TEGDK Click to Show/Hide
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| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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There is no similarity protein (E value < 0.005) for this target
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| References | Top | |||||
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| REF 1 | The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. | |||||
| REF 2 | Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. | |||||
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