Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T92714
(Former ID: TTDR01347)
|
|||||
| Target Name |
MADH6 messenger RNA (MADH6 mRNA)
|
|||||
| Synonyms |
hSMAD6 (mRNA); Smad6 (mRNA); SMAD family member 6 (mRNA); SMAD 6 (mRNA); Mothers against decapentaplegic homolog 6 (mRNA); Mothers against DPP homolog 6 (mRNA); MADH6 (mRNA); MAD homolog 6 (mRNA)
Click to Show/Hide
|
|||||
| Gene Name |
SMAD6
|
|||||
| Target Type |
Literature-reported target
|
[1] | ||||
| Function |
Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. Acts as a mediator of TGF-beta and BMP antiflammatory activity.
Click to Show/Hide
|
|||||
| BioChemical Class |
mRNA target
|
|||||
| UniProt ID | ||||||
| Sequence |
MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEV
RPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESD CETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLL KRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVE LKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSY TETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDL PQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAP GGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQF ITSCPCWLEILLNNPR Click to Show/Hide
|
|||||
| HIT2.0 ID | T16SLA | |||||
| Cell-based Target Expression Variations | Top | |||||
|---|---|---|---|---|---|---|
| Cell-based Target Expression Variations | ||||||
| Target Affiliated Biological Pathways | Top | |||||
|---|---|---|---|---|---|---|
| KEGG Pathway | [+] 2 KEGG Pathways | + | ||||
| 1 | Endocytosis | |||||
| 2 | TGF-beta signaling pathway | |||||
| Panther Pathway | [+] 1 Panther Pathways | + | ||||
| 1 | TGF-beta signaling pathway | |||||
| PID Pathway | [+] 1 PID Pathways | + | ||||
| 1 | BMP receptor signaling | |||||
| WikiPathways | [+] 7 WikiPathways | + | ||||
| 1 | TGF Beta Signaling Pathway | |||||
| 2 | Mesodermal Commitment Pathway | |||||
| 3 | Signaling by BMP | |||||
| 4 | Integrated Pancreatic Cancer Pathway | |||||
| 5 | Integrated Breast Cancer Pathway | |||||
| 6 | Regulation of toll-like receptor signaling pathway | |||||
| 7 | BMP Signalling and Regulation | |||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | US patent application no. 6,277,636, Antisense inhibition of MADH6 expression. | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.