Target Information

Content Navigation (  All   None )                                      
Target General Information
Different Human System Profiles of Target
Target Affiliated Biological Pathways
References
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Human Similarity Proteins
Human Pathway Affiliation
Protein Name Pfam ID Percentage of Identity (%) E value
E3 ubiquitin-protein ligase RAD18 (RAD18)
PF02037 ; 
PF13923
33.333 (24/72) 1.53E-05
E3 ubiquitin-protein ligase TRIM32 (TRIM32)
PF01436 ; 
PF13445
25.157 (40/159) 2.10E-04
Tripartite motif-containing protein 43 (TRIM43)
PF00622 ; 
PF15227
21.854 (66/302) 3.90E-04
E3 ubiquitin-protein ligase RNF5 (RNF5)
PF13920
35.185 (19/54) 5.76E-04
Tripartite motif-containing protein 43B (TRIM43B)
PF00622 ; 
PF15227
21.854 (66/302) 1.00E-03
E3 ubiquitin-protein ligase Topors (TOPORS)
PF13920
28.889 (13/45) 4.00E-03
  Click to Show/Hide the Information of Human Similarity Proteins
 Download Picture         KEGG Link      
KEGG Pathway Pathway ID Affiliated Target Pathway Map
Ubiquitin mediated proteolysis hsa04120 Affiliated Target
  Class: Genetic Information Processing => Folding, sorting and degradation Pathway Hierarchy

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.