Target Information

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Target General Information
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
References
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Similarity Proteins
Human Tissue Distribution
Protein Name Pfam ID Percentage of Identity (%) E value
Mixed lineage kinase 1 (MAP3K9)
PF00069 ; 
PF14604
32.959 (88/267) 1.08E-31
SPS1/STE20-related protein kinase YSK4 (YSK4)
PF00069
28.986 (60/207) 1.50E-21
Hormonally up-regulated neu tumor-associated kinase (HUNK)
PF00069
27.097 (84/310) 5.99E-20
MAPK/ERK kinase kinase 3 (MAP3K3)
PF00564 ; 
PF00069
29.493 (64/217) 2.57E-19
MST-1 protein kinase (STK4)
PF11629 ; 
PF00069
26.394 (71/269) 4.56E-19
Serine/threonine-protein kinase 3 (STK3)
PF11629 ; 
PF00069
25.965 (74/285) 4.91E-19
NIMA-related kinase 7 (NEK7)
PF00069
25.000 (74/296) 6.47E-18
Unc-51 like kinase 3 (ULK3)
PF04212 ; 
PF00069
28.137 (74/263) 2.62E-17
Serine/threonine-protein kinase ULK1 (ULK1)
PF12063 ; 
PF00069
27.344 (70/256) 2.96E-17
NIMA-related kinase 1 (NEK1)
PF00069
23.954 (63/263) 4.25E-17
Oxidative stress responsive 1 (OXSR1)
PF12202 ; 
PF00069
26.909 (74/275) 6.44E-17
Serine/threonine-protein kinase MARK1 (MARK1)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 28.916 (72/249) 8.97E-17
Ste-20-related kinase (STK39)
PF12202 ; 
PF00069
26.761 (76/284) 9.10E-17
MAPK/ERK kinase kinase 2 (MAP3K2)
PF00564 ; 
PF00069
27.778 (60/216) 1.31E-16
Serine/threonine-protein kinase 24 (STK24)
PF00069
26.855 (76/283) 2.01E-16
Aurora kinase A (AURKA)
PF00069
27.490 (69/251) 2.38E-16
PAK-1 protein kinase (PAK1)
PF00786 ; 
PF00069
27.027 (60/222) 3.19E-16
Serine/threonine-protein kinase PAK 3 (PAK3)
PF00786 ; 
PF00069
27.477 (61/222) 3.23E-16
Maternal embryonic leucine zipper kinase (MELK)
PF02149 ; 
PF00069
27.228 (55/202) 7.31E-16
Serine/threonine-protein kinase Nek8 (NEK8)
PF00069 ; 
PF00415
27.336 (79/289) 8.75E-16
Serine/threonine-protein kinase PAK 5 (PAK5)
PF00786 ; 
PF00069
26.667 (60/225) 1.00E-15
PAK-2 protein kinase (PAK2)
PF00786 ; 
PF00069
27.928 (62/222) 1.01E-15
Serine/threonine-protein kinase 10 (STK10)
PF00069 ; 
PF12474
26.568 (72/271) 1.10E-15
Serine/threonine-protein kinase 26 (STK26)
PF00069
27.434 (62/226) 1.17E-15
Serine/threonine-protein kinase MARK2 (MARK2)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 30.392 (62/204) 1.28E-15
Serine/threonine-protein kinase ULK2 (ULK2)
PF12063 ; 
PF00069
27.731 (66/238) 1.43E-15
Serine/threonine-protein kinase 25 (STK25)
PF00069
26.222 (59/225) 1.44E-15
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
PF00069 ; 
PF12721
29.964 (83/277) 1.52E-15
NIMA-related kinase 6 (NEK6)
PF00069
22.483 (67/298) 1.67E-15
Microtubule affinity regulating kinase 3 (MARK3)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 29.902 (61/204) 2.76E-15
STE20-related serine/threonine-protein kinase (SLK)
PF00069 ; 
PF12474
27.941 (57/204) 3.15E-15
PAS domain-containing serine/threonine-protein kinase (PASK)
PF13426 ; 
PF00069
28.421 (81/285) 3.40E-15
MEK kinase kinase 2 (MAP4K2)
PF00780 ; 
PF00069
30.288 (63/208) 4.14E-15
Calcium/calmodulin-dependent protein kinase type IV (CAMK4)
PF00069
29.268 (60/205) 5.37E-15
Cyclin-dependent kinase 1 (CDK1)
PF00069
27.723 (56/202) 5.80E-15
PAK-4 protein kinase (PAK4)
PF00786 ; 
PF00069
27.007 (74/274) 6.79E-15
BR serine/threonine kinase 2 (BRSK2)
PF00069
29.703 (60/202) 7.80E-15
Serine/threonine-protein kinase PAK 6 (PAK6)
PF00786 ; 
PF00069
25.909 (57/220) 8.72E-15
MAP/microtubule affinity-regulating kinase 4 (MARK4)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 29.208 (59/202) 9.02E-15
Serine/threonine-protein kinase NIM1 (NIM1K)
PF00069
31.553 (65/206) 1.13E-14
Omphalocele kinase 1 (NUAK1)
PF00069
28.814 (68/236) 1.16E-14
Cyclin-dependent kinase 3 (CDK3)
PF00069
29.064 (59/203) 1.22E-14
Serine/threonine-protein kinase 33 (STK33)
PF00069
27.556 (62/225) 1.37E-14
Aurora kinase C (AURKC)
PF00069
28.141 (56/199) 1.47E-14
Salt-inducible kinase 2 (SIK2)
PF00069
28.679 (76/265) 1.53E-14
Polo-like kinase 4 (PLK4)
PF00069 ; 
PF18190 ; 
PF18409
More >>
 27.451 (56/204) 1.66E-14
Myosin light chain kinase 3 (MYLK3)
PF00069
28.365 (59/208) 1.90E-14
Cyclin-dependent kinase 11A (CDK11A)
PF00069
25.974 (60/231) 2.77E-14
Cyclin-dependent kinase 10 (CDK10)
PF00069
29.648 (59/199) 2.89E-14
NUAK family SNF1-like kinase 2 (NUAK2)
PF00069
27.876 (63/226) 3.36E-14
Cyclin-dependent kinase 11B (CDK11B)
PF00069
26.724 (62/232) 3.45E-14
Cytoplasmic DRAK1 (STK17A)
PF00069
28.774 (61/212) 4.73E-14
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)
PF00780 ; 
PF00069
26.866 (54/201) 5.04E-14
Protein kinase D (PRKD1)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 29.268 (60/205) 5.38E-14
Cyclin-dependent kinase 2 (CDK2)
PF00069
29.126 (60/206) 5.81E-14
Death-associated protein kinase 3 (DAPK3)
PF00069
26.168 (56/214) 6.34E-14
BR serine/threonine kinase 1 (BRSK1)
PF00069
27.451 (56/204) 7.51E-14
Serine/threonine-protein kinase SBK1 (SBK1)
PF00069
30.952 (78/252) 7.57E-14
Cyclin-dependent kinase 17 (CDK17)
PF12330 ; 
PF00069
29.612 (61/206) 8.02E-14
SIK family kinase 3 (SIK3)
PF00069
28.713 (58/202) 1.01E-13
Cyclin-dependent kinase 6 (CDK6)
PF00069
28.636 (63/220) 1.15E-13
Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1)
PF12796 ; 
PF16095 ; 
PF00069 ; 
PF08477
More >>
 25.872 (89/344) 1.22E-13
Serine/threonine-protein kinase D3 (PRKD3)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 29.268 (60/205) 1.57E-13
Cyclin-dependent kinase 14 (CDK14)
PF00069
28.079 (57/203) 2.12E-13
Calmodulin-dependent kinase II (CAMKK2)
PF00069
29.515 (67/227) 2.29E-13
Serine/threonine-protein kinase Nek11 (NEK11)
PF00069
25.854 (53/205) 2.66E-13
Nik-related protein kinase (NRK)
PF00780 ; 
PF00069
24.684 (78/316) 2.79E-13
MEK kinase kinase 3 (MAP4K3)
PF00780 ; 
PF00069
26.866 (54/201) 3.08E-13
Death-associated protein kinase 1 (DAPK1)
PF00023 ; 
PF12796 ; 
PF13637 ; 
PF00531 ; 
PF00069
More >>
 28.372 (61/215) 3.83E-13
Fused homolog (STK36)
PF13646 ; 
PF00069
26.991 (61/226) 4.26E-13
Cyclin-dependent kinase 15 (CDK15)
PF00069
28.571 (58/203) 4.64E-13
Calcium/calmodulin-dependent protein kinase type 1B (PNCK)
PF00069
31.731 (66/208) 5.19E-13
Polo-like kinase 1 (PLK1)
PF00069 ; 
PF00659
29.245 (62/212) 5.68E-13
Testis-specific serine kinase 2 (TSSK2)
PF00069
25.455 (56/220) 6.08E-13
Myosin light chain kinase family member 4 (MYLK4)
PF00069
25.359 (53/209) 6.57E-13
TAO kinase 3 (TAOK3)
PF00069
30.049 (61/203) 7.11E-13
Serine/threonine-protein kinase Nek5 (NEK5)
PF00069
23.438 (60/256) 7.65E-13
Proto-oncogene serine/threonine-protein kinase mos (MOS)
PF00069
23.448 (68/290) 8.20E-13
Serine/threonine-protein kinase PLK3 (PLK3)
PF00069 ; 
PF00659
27.731 (66/238) 8.29E-13
Serine/threonine-protein kinase 32A (STK32A)
PF00069
27.679 (62/224) 8.51E-13
MEK kinase kinase 1 (MAP4K1)
PF00780 ; 
PF00069
26.866 (54/201) 1.03E-12
Serine/threonine-protein kinase Chk2 (RAD53)
PF00498 ; 
PF00069
29.560 (47/159) 1.07E-12
Serine/threonine-protein kinase D2 (PRKD2)
PF00130 ; 
PF00069
29.756 (61/205) 1.19E-12
Myosin light kinase (MYLK)
PF16620 ; 
PF00041 ; 
PF07679 ; 
PF00069
More >>
 28.641 (59/206) 1.28E-12
Cyclin-dependent kinase 16 (CDK16)
PF12330 ; 
PF00069
28.431 (58/204) 1.30E-12
Ribosomal protein S6 kinase alpha-3 (RSK3)
PF00069 ; 
PF00433
25.000 (65/260) 1.58E-12
Doublecortin-like kinase 3 (DCLK3)
PF00069
26.217 (70/267) 1.70E-12
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)
PF08332 ; 
PF00069
26.961 (55/204) 1.73E-12
Cyclin-dependent kinase 18 (CDK18)
PF00069
29.412 (60/204) 2.48E-12
Putative serine/threonine-protein kinase SIK1B (SIK1B)
PF00069
28.352 (74/261) 2.51E-12
Salt-inducible kinase 1 (SIK1)
PF00069
28.352 (74/261) 2.60E-12
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
PF16579 ; 
PF00069
29.524 (62/210) 3.21E-12
Ribosomal protein S6 kinase alpha-6 (RSK6)
PF00069 ; 
PF00433
25.692 (65/253) 3.25E-12
Ribosomal protein S6 kinase alpha-1 (RSK1)
PF00069 ; 
PF00433
26.733 (54/202) 3.28E-12
TAO kinase 1 (TAOK1)
PF00069
29.756 (61/205) 3.40E-12
Testis-specific serine/threonine-protein kinase 4 (TSSK4)
PF00069
26.906 (60/223) 4.00E-12
cAMP-dependent protein kinase catalytic subunit gamma (PRKACG)
PF00069
27.374 (49/179) 4.05E-12
Serine/threonine-protein kinase SBK2 (SBK2)
PF00069
34.928 (73/209) 4.19E-12
Cyclin-dependent kinase 4 (CDK4)
PF00069
30.244 (62/205) 4.43E-12
Checkpoint kinase-1 (CHK1)
PF00069
26.887 (57/212) 4.81E-12
Ribosomal protein S6 kinase beta-2 (RPS6KB2)
PF00069 ; 
PF00433
23.529 (60/255) 5.16E-12
Polo-like kinase 2 (PLK2)
PF00069 ; 
PF00659
25.839 (77/298) 5.73E-12
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)
PF08332 ; 
PF00069
25.980 (53/204) 5.80E-12
Ribosomal protein S6 kinase alpha-2 (RSK2)
PF00069 ; 
PF00433
27.632 (63/228) 6.87E-12
Phosphoinositide dependent protein kinase-1 (PDPK1)
PF14593 ; 
PF00069
22.747 (53/233) 7.06E-12
Putative 3-phosphoinositide-dependent protein kinase 2 (PDPK2P)
PF00069
24.324 (45/185) 7.20E-12
TRAF2 and NCK interacting kinase (TNIK)
PF00780 ; 
PF00069
24.262 (74/305) 7.23E-12
Death-associated protein kinase 2 (DAPK2)
PF00069
25.701 (55/214) 7.36E-12
WNK lysine-deficient protein kinase 3 (WNK3)
PF12202 ; 
PF00069
25.472 (54/212) 7.61E-12
Protein kinase C alpha (PRKCA)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 26.667 (52/195) 7.66E-12
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)
PF00069
28.641 (59/206) 7.79E-12
Protein kinase C theta (PRKCQ)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 26.971 (65/241) 8.40E-12
MAPK/ERK kinase kinase 1 (MAP3K1)
PF00069
25.175 (72/286) 9.91E-12
Serine/threonine-protein kinase 17B (STK17B)
PF00069
26.066 (55/211) 1.01E-11
RAC-beta serine/threonine-protein kinase (AKT2)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 28.922 (59/204) 1.04E-11
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)
PF08332 ; 
PF00069
26.961 (55/204) 1.07E-11
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
PF00069
28.293 (58/205) 1.08E-11
SNF-related serine/threonine-protein kinase (SNRK)
PF00069
26.022 (70/269) 1.15E-11
Peripheral plasma membrane protein CASK (CASK)
PF00625 ; 
PF02828 ; 
PF00595 ; 
PF00069 ; 
PF00018
More >>
 28.293 (58/205) 1.54E-11
Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G)
PF00069
27.451 (56/204) 2.08E-11
Leucine-rich repeat kinase 2 (LRRK2)
PF16095 ; 
PF12799 ; 
PF13855 ; 
PF00069 ; 
PF08477
More >>
 25.313 (81/320) 2.08E-11
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
PF16579 ; 
PF00069
28.230 (59/209) 2.21E-11
Extracellular signal-regulated kinase 2 (ERK2)
PF00069
24.000 (48/200) 2.24E-11
Yet another novel kinase 2 (STK32B)
PF00069
27.879 (46/165) 2.36E-11
Ribosomal protein S6 kinase alpha-5 (RSK5)
PF00069 ; 
PF00433
26.699 (55/206) 2.40E-11
CaM-kinase IV kinase (CAMKK1)
PF00069
28.230 (59/209) 2.47E-11
Serine/threonine-protein kinase TAO2 (TAOK2)
PF00069
29.000 (58/200) 2.84E-11
Cyclin-dependent kinase 5 (CDK5)
PF00069
26.699 (55/206) 2.95E-11
Aurora kinase B (AURKB)
PF00069
27.094 (55/203) 3.63E-11
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)
PF00069
28.571 (62/217) 3.76E-11
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)
PF08332 ; 
PF00069
26.471 (54/204) 3.76E-11
Misshapen-like kinase 1 (MINK1)
PF00780 ; 
PF00069
24.664 (55/223) 3.94E-11
NIMA-related kinase 2 (NEK2)
PF00069
26.250 (42/160) 3.97E-11
PKC-delta-interacting protein kinase (RIPK4)
PF12796 ; 
PF00069
28.571 (76/266) 5.30E-11
Serine/threonine-protein kinase STK11 (STK11)
PF00069
28.270 (67/237) 5.34E-11
Protein kinase C beta (PRKCB)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 25.641 (50/195) 5.71E-11
Putative serine/threonine-protein kinase PRKY (PRKY)
PF00069
28.311 (62/219) 5.73E-11
Myosin-IIIa (MYO3A)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 24.101 (67/278) 6.52E-11
RAC-gamma serine/threonine-protein kinase (AKT3)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 27.805 (57/205) 7.23E-11
MAPK/ERK kinase kinase 4 (MAP3K4)
PF19431 ; 
PF00069
26.389 (57/216) 7.66E-11
Serine/threonine-protein kinase H2 (PSKH2)
PF00069
29.469 (61/207) 7.86E-11
Serine/threonine-protein kinase Nek9 (NEK9)
PF00069 ; 
PF00415
22.066 (47/213) 9.47E-11
Extracellular signal-regulated kinase 1 (ERK1)
PF00069
23.645 (48/203) 9.72E-11
Ribosomal protein S6 kinase beta-1 (S6K1)
PF00069 ; 
PF00433
21.168 (58/274) 1.06E-10
Protein kinase C iota (PRKCI)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 28.571 (52/182) 1.20E-10
Serine/threonine-protein kinase Nek3 (NEK3)
PF00069
21.905 (69/315) 1.44E-10
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)
PF00069
26.087 (60/230) 1.47E-10
Serine/threonine-protein kinase WNK1 (WNK1)
PF12202 ; 
PF00069
25.000 (53/212) 1.48E-10
Serine/threonine-protein kinase Nek4 (NEK4)
PF00069
25.468 (68/267) 1.48E-10
Serine/threonine-protein kinase WNK4 (WNK4)
PF12202 ; 
PF00069
27.354 (61/223) 1.71E-10
Testis-specific serine/threonine-protein kinase 6 (TSSK6)
PF00069
28.947 (66/228) 2.28E-10
Protein kinase G1 (PRKG1)
PF00027 ; 
PF16808 ; 
PF00069
More >>
 25.969 (67/258) 2.31E-10
Doublecortin-like kinase 2 (DCLK2)
PF03607 ; 
PF00069
25.962 (54/208) 2.89E-10
ERK activator kinase 5 (MAP2K5)
PF00564 ; 
PF00069
22.403 (69/308) 3.20E-10
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
PF00069
23.596 (63/267) 3.99E-10
Serine/threonine-protein kinase Nek10 (NEK10)
PF00069
23.810 (65/273) 4.32E-10
RAC-alpha serine/threonine-protein kinase (AKT1)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 28.431 (58/204) 4.49E-10
Doublecortin-like kinase 1 (DCLK1)
PF03607 ; 
PF00069
26.570 (55/207) 4.57E-10
Ribosomal protein S6 kinase-related protein (RSKR)
PF00069
29.412 (45/153) 5.76E-10
Myosin light chain kinase 2 (MYLK2)
PF00069
24.020 (49/204) 6.99E-10
Obscurin (OBSCN)
PF00041 ; 
PF07679 ; 
PF00612 ; 
PF00069 ; 
PF00621
More >>
 25.581 (55/215) 7.21E-10
Protein kinase C delta (PRKCD)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 26.106 (59/226) 7.29E-10
PRKR-like endoplasmic reticulum kinase (PERK)
PF00069
28.221 (46/163) 7.57E-10
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
PF00069
25.000 (60/240) 8.93E-10
NF-kappa-B-activating kinase (TBK1)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 24.699 (41/166) 9.66E-10
MEK kinase kinase 4 (MAP4K4)
PF00780 ; 
PF00069
24.215 (54/223) 1.03E-09
Glycogen synthase kinase-3 alpha (GSK-3A)
PF00069
28.571 (64/224) 1.07E-09
Protein kinase G2 (PRKG2)
PF00027 ; 
PF00069
24.609 (63/256) 1.08E-09
Apoptosis signal-regulating kinase 2 (MAP3K6)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 26.996 (71/263) 1.10E-09
Glycogen synthase kinase-3 beta (GSK-3B)
PF00069
27.477 (61/222) 1.22E-09
Microtubule-associated serine/threonine-protein kinase 4 (MAST4)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 27.103 (58/214) 1.78E-09
Serine/threonine-protein kinase NLK (NLK)
PF00069
28.571 (60/210) 1.80E-09
Serine/threonine-protein kinase PDIK1L (PDIK1L)
PF00069
24.016 (61/254) 1.81E-09
Serine/threonine-protein kinase Sgk3 (SGK3)
PF00069 ; 
PF00433 ; 
PF00787
More >>
 24.590 (60/244) 2.09E-09
Protein kinase C gamma (PRKCG)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 26.712 (39/146) 2.72E-09
Cyclin-dependent kinase-like 5 (CDKL5)
PF00069
25.243 (52/206) 2.77E-09
Myosin-IIIb (MYO3B)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 23.381 (65/278) 2.83E-09
Testis-specific serine/threonine-protein kinase 1 (TSSK1B)
PF00069
29.016 (56/193) 3.29E-09
Mitogen-activated protein kinase kinase kinase 15 (MAP3K15)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 24.188 (67/277) 3.92E-09
Cyclin-dependent kinase-like 1 (CDKL1)
PF00069
25.871 (52/201) 4.16E-09
Serine/threonine-protein kinase MAK (MAK)
PF00069
28.481 (45/158) 4.33E-09
Extracellular signal-regulated kinase 5 (ERK5)
PF00069
24.038 (50/208) 4.33E-09
Testis-specific serine/threonine-protein kinase 3 (TSSK3)
PF00069
27.053 (56/207) 4.56E-09
Serine/threonine-protein kinase WNK2 (WNK2)
PF12202 ; 
PF00069
25.000 (53/212) 5.08E-09
Protein kinase C zeta (PRKCZ)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 30.769 (40/130) 5.53E-09
Serine/threonine-protein kinase ICK (CILK1)
PF00069
27.094 (55/203) 5.70E-09
Microtubule-associated serine/threonine-protein kinase 3 (MAST3)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 25.610 (63/246) 6.38E-09
Serine/threonine-protein kinase H1 (PSKH1)
PF00069
30.189 (48/159) 6.72E-09
Cyclin-dependent kinase 13 (CDK13)
PF12330 ; 
PF00069
24.424 (53/217) 6.90E-09
Apoptosis signal-regulating kinase 1 (MAP3K5)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 23.684 (63/266) 7.26E-09
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1)
PF00069
26.941 (59/219) 8.30E-09
ERK activator kinase 2 (MEK2)
PF00069
25.500 (51/200) 8.37E-09
IL-1 receptor-associated kinase 1 (IRAK1)
PF00531 ; 
PF00069
27.230 (58/213) 9.08E-09
ERK activator kinase 1 (MEK1)
PF00069
25.000 (50/200) 9.09E-09
Tyrosine-protein kinase EIF2AK2 (p68)
PF00035 ; 
PF00069
22.807 (52/228) 1.04E-08
Cyclin-dependent kinase 12 (CDK12)
PF00069
23.963 (52/217) 1.11E-08
Serine/threonine-protein kinase/endoribonuclease IRE2 (ERN2)
PF00069 ; 
PF06479
27.755 (68/245) 1.16E-08
Stress-activated protein kinase JNK3 (JNK3)
PF00069
26.415 (42/159) 1.44E-08
Inhibitor of nuclear factor kappa-B kinase alpha (IKKA)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 25.581 (55/215) 1.49E-08
Protein kinase C epsilon (PRKCE)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 26.316 (55/209) 1.93E-08
Cyclin-dependent kinase-like 4 (CDKL4)
PF00069
26.339 (59/224) 1.97E-08
Phosphorylase kinase testis gamma 2 (PHKG2)
PF00069
26.147 (57/218) 2.00E-08
Stress-activated protein kinase JNK2 (JNK2)
PF00069
25.481 (53/208) 2.15E-08
Serine/threonine-protein kinase Sgk1 (SGK1)
PF00069 ; 
PF00433
26.961 (55/204) 2.21E-08
Cyclin-dependent kinase-like 2 (CDKL2)
PF00069
24.138 (49/203) 2.29E-08
Microtubule-associated serine/threonine-protein kinase 2 (MAST2)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 27.368 (52/190) 4.10E-08
Stress-activated protein kinase JNK1 (JNK1)
PF00069
27.044 (43/159) 5.47E-08
Membrane-associated kinase (PKMYT1)
PF00069
36.893 (38/103) 5.64E-08
Endoplasmic reticulum to nucleus signaling 1 (ERN1)
PF00069 ; 
PF06479
25.764 (59/229) 5.66E-08
Cyclin-dependent kinase 7 (CDK7)
PF00069
23.645 (48/203) 5.91E-08
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
PF00069
23.596 (63/267) 9.66E-08
Microtubule-associated serine/threonine-protein kinase 1 (MAST1)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 22.917 (77/336) 1.01E-07
Protein kinase N2 (PKN2)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 28.448 (66/232) 1.01E-07
Inhibitor of nuclear factor kappa-B kinase beta (IKKB)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 27.982 (61/218) 1.48E-07
Striated muscle preferentially expressed protein kinase (SPEG)
PF07679 ; 
PF00069 ; 
PF16650
More >>
 26.667 (44/165) 1.59E-07
Titin (TTN) 27.805 (57/205) 1.73E-07
Protein kinase C eta type (PRKCH)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 31.633 (31/98) 1.90E-07
Cyclin-dependent kinase 20 (CDK20)
PF00069
25.962 (54/208) 2.88E-07
Serine/threonine-protein kinase 32C (STK32C)
PF00069
24.242 (40/165) 3.30E-07
Serine/threonine-protein kinase 35 (STK35)
PF00069
25.591 (65/254) 4.55E-07
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)
PF00069
25.904 (43/166) 5.18E-07
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 27.485 (47/171) 5.96E-07
MAPK/MAK/MRK overlapping kinase (MOK)
PF00069
23.301 (48/206) 6.03E-07
Rho-associated protein kinase 1 (ROCK1)
PF00069 ; 
PF08912
26.794 (56/209) 6.47E-07
Serine/threonine kinase-like domain-containing protein STKLD1 (STKLD1)
PF00069
24.859 (44/177) 6.64E-07
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
PF00069
24.757 (51/206) 6.86E-07
Serine/threonine-protein kinase ULK4 (ULK4)
PF00069
26.141 (63/241) 6.91E-07
Homeodomain-interacting protein kinase 4 (HIPK4)
PF00069
26.087 (66/253) 7.75E-07
Sugen kinase 110 (SBK3)
PF00069
36.478 (58/159) 8.26E-07
Serine/threonine-protein kinase pim-2 (PIM2)
PF00069
26.909 (74/275) 8.65E-07
IL-1 receptor-associated kinase 3 (IRAK3)
PF00531 ; 
PF00069
22.456 (64/285) 8.75E-07
Cyclin-dependent kinase-like 3 (CDKL3)
PF00069
28.571 (28/98) 9.59E-07
Protein kinase N1 (PKN1)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 28.879 (67/232) 9.82E-07
Serine/threonine-protein kinase Sgk2 (SGK2)
PF00069 ; 
PF00433
27.273 (45/165) 1.23E-06
MAPK-activated protein kinase 2 (MAPKAPK2)
PF00069
26.000 (39/150) 1.24E-06
PDZ binding kinase (PBK)
PF00069
22.541 (55/244) 1.30E-06
Rho-associated protein kinase 2 (ROCK2)
PF00069 ; 
PF08912
25.962 (54/208) 1.31E-06
Mitogen-activated protein kinase 6 (MAPK6)
PF00069
26.471 (45/170) 1.62E-06
TBC domain-containing protein kinase-like protein (TBCK)
PF00069 ; 
PF00566 ; 
PF00581
More >>
 30.435 (35/115) 1.87E-06
Mitogen-activated protein kinase 4 (MAPK4)
PF00069
22.222 (46/207) 2.04E-06
Bone morphogenetic protein receptor (BMPR2)
PF01064 ; 
PF00069
25.296 (64/253) 2.80E-06
Cyclin-dependent kinase 19 (CDK19)
PF00069
24.405 (41/168) 2.96E-06
Homeodomain interacting protein kinase 2 (HIPK2)
PF00069
25.676 (57/222) 2.99E-06
Cyclin-dependent kinase 8 (CDK8)
PF00069
24.405 (41/168) 4.09E-06
Mitogen-activated protein kinase 15 (MAPK15)
PF00069
25.893 (58/224) 4.93E-06
Serine/threonine-protein kinase pim-1 (PIM1)
PF00069
25.088 (71/283) 5.56E-06
Serine/threonine-protein kinase Kist (UHMK1)
PF00069 ; 
PF00076
35.354 (35/99) 5.71E-06
ERK activator kinase 7 (MAP2K7)
PF00069
23.106 (61/264) 6.85E-06
MAP kinase p38 (MAPK12)
PF00069
23.671 (49/207) 7.47E-06
Rhodopsin kinase GRK1 (GRK1)
PF00069 ; 
PF00615
28.571 (28/98) 8.20E-06
CDC42 binding protein kinase alpha (DMPK-like alpha)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069 ; 
PF00433
More >>
 25.424 (60/236) 1.08E-05
MAPK-activated protein kinase 3 (MAPKAPK3)
PF00069
26.531 (26/98) 1.25E-05
Ribosomal protein S6 kinase alpha-4 (RPS6KA4)
PF00069 ; 
PF00433
27.230 (58/213) 1.27E-05
Serine/threonine-protein kinase cot (COT)
PF00069
22.093 (38/172) 1.65E-05
Serine/threonine-protein kinase PRP4 homolog (PRPF4B)
PF00069
25.373 (51/201) 1.95E-05
Homeodomain-interacting protein kinase 3 (HIPK3)
PF00069
24.775 (55/222) 1.99E-05
Mitogen-activated protein kinase 13 (MAPK13)
PF00069
27.692 (36/130) 2.07E-05
Homeodomain-interacting protein kinase 1 (HIPK1)
PF00069
27.315 (59/216) 2.79E-05
Protein kinase N3 (PKN3)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 33.088 (45/136) 4.23E-05
Myotonin-protein kinase (DMPK)
PF08826 ; 
PF00069
27.647 (47/170) 4.33E-05
NDR1 protein kinase (STK38)
PF00069 ; 
PF00433
23.492 (74/315) 5.89E-05
NDR2 protein kinase (STK38L)
PF00069 ; 
PF00433
23.125 (37/160) 5.99E-05
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)
PF00069
29.457 (38/129) 6.12E-05
Citron Rho-interacting kinase (CIT)
PF00780 ; 
PF00169 ; 
PF00069
More >>
 28.889 (39/135) 7.22E-05
Eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4)
PF12745 ; 
PF00069 ; 
PF05773 ; 
PF13393
More >>
 25.620 (31/121) 7.50E-05
TGF-beta receptor type I (TGFBR1)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 25.688 (56/218) 9.22E-05
Tribbles homolog 2 (TRIB2)
PF00069
24.260 (41/169) 1.14E-04
Stress-activated protein kinase 2a (p38 alpha)
PF00069
22.772 (46/202) 1.32E-04
Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B)
PF00069
30.928 (30/97) 1.53E-04
Activin receptor type IB (ACVR1B)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 25.424 (60/236) 1.59E-04
Serine/threonine-protein kinase LATS1 (LATS1)
PF00069 ; 
PF00627
20.714 (58/280) 1.60E-04
Serine/threonine-protein kinase MRCK beta (CDC42BPB)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069
More >>
 24.576 (58/236) 2.14E-04
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)
PF00531 ; 
PF00069
24.257 (49/202) 2.41E-04
CaM kinase-like vesicle-associated protein (CAMKV)
PF00069
23.214 (39/168) 2.66E-04
Rhodopsin kinase GRK7 (GRK7)
PF00069 ; 
PF00615
24.359 (38/156) 3.13E-04
Serine/threonine-protein kinase NIK (MAP3K14)
PF00069
27.488 (58/211) 3.41E-04
Stress-activated protein kinase 2b (p38 beta)
PF00069
23.567 (37/157) 3.58E-04
Tribbles homolog 3 (TRIB3)
PF00069
27.381 (46/168) 3.62E-04
Serine/threonine-protein kinase greatwall (MASTL)
PF00069
38.636 (17/44) 3.76E-04
Beta-adrenergic receptor kinase 1 (ADRBK1)
PF00169 ; 
PF00069 ; 
PF00615
More >>
 23.256 (30/129) 4.52E-04
G protein-coupled receptor kinase 6 (GRK6)
PF00069 ; 
PF00615
26.042 (25/96) 5.19E-04
Triple functional domain protein (TRIO)
PF00650 ; 
PF07679 ; 
PF00169 ; 
PF00069 ; 
PF00621 ; 
PF16609 ; 
PF00018 ; 
PF00435
More >>
 27.523 (60/218) 6.47E-04
G protein-coupled receptor kinase 4 (GRK4)
PF00069 ; 
PF00615
27.083 (26/96) 7.27E-04
Cyclin-dependent kinase 9 (CDK9)
PF00069
22.535 (48/213) 8.46E-04
MAP kinase signal-integrating kinase 2 (MKNK2)
PF00069
26.316 (30/114) 1.00E-03
Kalirin (KALRN)
PF13716 ; 
PF00041 ; 
PF07679 ; 
PF00169 ; 
PF00069 ; 
PF00621 ; 
PF16609 ; 
PF00435
More >>
 25.731 (44/171) 1.00E-03
Serine/threonine-protein kinase MRCK gamma (CDC42BPG)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF00069
More >>
 27.041 (53/196) 2.00E-03
MAPK-activated protein kinase 5 (MAPKAPK5)
PF00069
24.161 (36/149) 3.00E-03
G protein-coupled receptor kinase 5 (GRK5)
PF00069 ; 
PF00615
26.214 (27/103) 3.00E-03
  Click to Show/Hide the Information of Human Similarity Proteins
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.

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