Target Information
| Target General Information | Top | |||||
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| Target ID |
T91292
(Former ID: TTDR00989)
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| Target Name |
MTHFR messenger RNA (MTHFR mRNA)
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| Synonyms |
Methylenetetrahydrofolate reductase (mRNA)
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| Gene Name |
MTHFR
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| EC Number |
EC 1.5.1.20
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| Sequence |
MVNEARGNSSLNPCLEGSASSGSESSKDSSRCSTPGLDPERHERLREKMRRRLESGDKWF
SLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNYC GLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPIGDQWEEEEGGFNYAVDLVK HIRSEFGDYFDICVAGYPKGHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFV KACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIE LAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDPRRPLPWALSAHPKRREE DVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKM WGEELTSEESVFEVFVLYLSGEPNRNGHKVTCLPWNDEPLAAETSLLKEELLRVNRQGIL TINSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHL VNVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYE EESPSRTIIQYIHDNYFLVNLVDNDFPLDNCLWQVVEDTLELLNRPTQNARETEAP Click to Show/Hide
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| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Target Affiliated Biological Pathways | Top | |||||
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| BioCyc | [+] 1 BioCyc Pathways | + | ||||
| 1 | Folate transformations I | |||||
| KEGG Pathway | [+] 3 KEGG Pathways | + | ||||
| 1 | One carbon pool by folate | |||||
| 2 | Metabolic pathways | |||||
| 3 | Carbon metabolism | |||||
| NetPath Pathway | [+] 2 NetPath Pathways | + | ||||
| 1 | IL4 Signaling Pathway | |||||
| 2 | TCR Signaling Pathway | |||||
| Pathwhiz Pathway | [+] 2 Pathwhiz Pathways | + | ||||
| 1 | Folate Metabolism | |||||
| 2 | Methionine Metabolism | |||||
| Reactome | [+] 1 Reactome Pathways | + | ||||
| 1 | Metabolism of folate and pterines | |||||
| WikiPathways | [+] 10 WikiPathways | + | ||||
| 1 | Trans-sulfuration and one carbon metabolism | |||||
| 2 | One Carbon Metabolism | |||||
| 3 | One carbon donor | |||||
| 4 | Metabolism of water-soluble vitamins and cofactors | |||||
| 5 | Folate Metabolism | |||||
| 6 | Fluoropyrimidine Activity | |||||
| 7 | Folate-Alcohol and Cancer Pathway | |||||
| 8 | Vitamin B12 Metabolism | |||||
| 9 | Selenium Micronutrient Network | |||||
| 10 | Glycine Metabolism | |||||
| References | Top | |||||
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| REF 1 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | |||||
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