Target Information
| Target General Information | Top | |||||
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| Target ID |
T91154
(Former ID: TTDR01425)
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| Target Name |
WWP1 messenger RNA (WWP1 mRNA)
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| Synonyms |
WW domain-containing protein 1 (mRNA); Tiul1 (mRNA); TGIF-interacting ubiquitin ligase 1 (mRNA); NEDD4-like E3 ubiquitin-protein ligase WWP1 (mRNA); HECT-type E3 ubiquitin transferase WWP1 (mRNA); Atrophin-1-interacting protein 5 (mRNA); AIP5 (mRNA)
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| Gene Name |
WWP1
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| EC Number |
EC 2.3.2.26
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| Sequence |
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSS
NPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLK LSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTAR LAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADD TVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTS AELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKD PHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNF EQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTK TTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQ IAYERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIF RGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFI GRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGL EMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGF NEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDN EVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYK SYEQLKEKLLFAIEETEGFGQE Click to Show/Hide
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| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Target Affiliated Biological Pathways | Top | |||||
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| KEGG Pathway | [+] 2 KEGG Pathways | + | ||||
| 1 | Ubiquitin mediated proteolysis | |||||
| 2 | Endocytosis | |||||
| Panther Pathway | [+] 1 Panther Pathways | + | ||||
| 1 | Ubiquitin proteasome pathway | |||||
| PID Pathway | [+] 4 PID Pathways | + | ||||
| 1 | ErbB4 signaling events | |||||
| 2 | Validated transcriptional targets of deltaNp63 isoforms | |||||
| 3 | Validated transcriptional targets of TAp63 isoforms | |||||
| 4 | TGF-beta receptor signaling | |||||
| Reactome | [+] 2 Reactome Pathways | + | ||||
| 1 | Stimuli-sensing channels | |||||
| 2 | Antigen processing: Ubiquitination & Proteasome degradation | |||||
| WikiPathways | [+] 3 WikiPathways | + | ||||
| 1 | TGF beta Signaling Pathway | |||||
| 2 | Signaling by ERBB4 | |||||
| 3 | Iron uptake and transport | |||||
| References | Top | |||||
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| REF 1 | US patent application no. 6,258,601, Antisense modulation of ubiquitin protein ligase expression. | |||||
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