Target Information
| Target General Information | Top | |||||
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| Target ID |
T89917
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| Target Name |
SARS-CoV helicase (Hel)
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| Synonyms |
SARS-CoV Helicase; SARS-CoV Hel
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| Gene Name |
SARS-CoV rep; SARS-CoV 1a-1b
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| Disease | [+] 3 Target-related Diseases | + | ||||
| 1 | Coronavirus infection [ICD-11: 1D92] | |||||
| 2 | Middle East Respiratory Syndrome [ICD-11: 1D64] | |||||
| 3 | Severe acute respiratory syndrome [ICD-11: 1D65] | |||||
| Function |
Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.
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| BioChemical Class |
Coronaviruses polyprotein 1ab family
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| UniProt ID | ||||||
| EC Number |
EC 3.6.4.12
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| Sequence |
AMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVC
NAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIA TCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVG KPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSH TVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSH FAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNS TLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRT LLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQ CFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPT QTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKIGILCIMSDRDLYDKLQFTSL E Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Drugs and Modes of Action | Top | |||||
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| Preclinical Drugs | [+] 2 | + | ||||
| 1 | PMID21925774-compound-5e | Drug Info | Preclinical | Severe acute respiratory syndrome (SARS) | [1] | |
| 2 | SSYA10-001 | Drug Info | Preclinical | Severe acute respiratory syndrome (SARS) | [2] | |
| Preclinical Drug(s) | [+] 1 Preclinical Drugs | + | ||||
| 1 | SSYA10-001 | Drug Info | Preclinical | Coronavirus infection | [2] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Inhibitor | [+] 3 Inhibitor drugs | + | ||||
| 1 | PMID21925774-compound-5e | Drug Info | [1] | |||
| 2 | SSYA10-001 | Drug Info | [2] | |||
| 3 | SSYA10-001 | Drug Info | [2] | |||
| Chemical Structure based Activity Landscape of Target | Top |
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| References | Top | |||||
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| REF 1 | 2,6-Bis-arylmethyloxy-5-hydroxychromones With Antiviral Activity Against Both Hepatitis C Virus (HCV) and SARS-associated Coronavirus (SCV) Eur J Med Chem. 2011 Nov;46(11):5698-704. | |||||
| REF 2 | Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. | |||||
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