Target Information
| Target General Information | Top | |||||
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| Target ID |
T89636
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| Target Name |
MERS-CoV helicase (Hel)
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| Synonyms |
MERS-CoV Helicase; MERS-CoV Hel
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| Gene Name |
MERS-CoV rep; MERS-CoV 1a-1b
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| Disease | [+] 2 Target-related Diseases | + | ||||
| 1 | Middle East Respiratory Syndrome [ICD-11: 1D64] | |||||
| 2 | Severe acute respiratory syndrome [ICD-11: 1D65] | |||||
| Function |
Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.
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| BioChemical Class |
Coronaviruses polyprotein 1ab family
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| UniProt ID | ||||||
| EC Number |
EC 3.6.4.12
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| Sequence |
AVGSCVVCHSQTSLRCGTCIRRPFLCCKCCYDHVIATPHKMVLSVSPYVCNAPGCGVSDV
TKLYLGGMSYFCVDHRPVCSFPLCANGLVFGLYKNMCTGSPSIVEFNRLATCDWTESGDY TLANTTTEPLKLFAAETLRATEEASKQSYAIATIKEIVGERQLLLVWEAGKSKPPLNRNY VFTGYHITKNSKVQLGEYIFERIDYSDAVSYKSSTTYKLTVGDIFVLTSHSVATLTAPTI VNQERYVKITGLYPTITVPEEFASHVANFQKSGYSKYVTVQGPPGTGKSHFAIGLAIYYP TARVVYTACSHAAVDALCEKAFKYLNIAKCSRIIPAKARVECYDRFKVNETNSQYLFSTI NALPETSADILVVDEVSMCTNYDLSIINARIKAKHIVYVGDPAQLPAPRTLLTRGTLEPE NFNSVTRLMCNLGPDIFLSMCYRCPKEIVSTVSALVYNNKLLAKKELSGQCFKILYKGNV THDASSAINRPQLTFVKNFITANPAWSKAVFISPYNSQNAVARSMLGLTTQTVDSSQGSE YQYVIFCQTADTAHANNINRFNVAITRAQKGILCVMTSQALFESLEFTELSFTNYKLQ Click to Show/Hide
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| Drugs and Modes of Action | Top | |||||
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| Preclinical Drugs | [+] 2 | + | ||||
| 1 | PMID31955138-compound-16 | Drug Info | Preclinical | Middle East Respiratory Syndrome (MERS) | [1] | |
| 2 | SSYA10-001 | Drug Info | Preclinical | Severe acute respiratory syndrome (SARS) | [2] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Inhibitor | [+] 2 Inhibitor drugs | + | ||||
| 1 | PMID31955138-compound-16 | Drug Info | [1] | |||
| 2 | SSYA10-001 | Drug Info | [2] | |||
| Chemical Structure based Activity Landscape of Target | Top |
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| References | Top | |||||
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| REF 1 | Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors. Acta Pharm. 2020 Jun 1;70(2):145-159. | |||||
| REF 2 | Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. | |||||
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