Target Information
Target General Information | Top | |||||
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Target ID |
T75386
(Former ID: TTDR01352)
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Target Name |
DGAT1 messenger RNA (DGAT1 mRNA)
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Synonyms |
Retinol O-fatty-acyltransferase (mRNA); Diglyceride acyltransferase (mRNA); Diacylglycerol O-acyltransferase 1 (mRNA); DGAT (mRNA); Acyl-CoA retinol O-fatty-acyltransferase (mRNA); ARAT (mRNA); AGRP1 (mRNA); ACAT-related gene product 1 (mRNA)
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Gene Name |
DGAT1
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Target Type |
Literature-reported target
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[1] | ||||
Function |
In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.
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BioChemical Class |
mRNA target
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UniProt ID | ||||||
EC Number |
EC 2.3.1.20
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Sequence |
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN YEAPAAEA Click to Show/Hide
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Cell-based Target Expression Variations | Top | |||||
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Cell-based Target Expression Variations |
Target Affiliated Biological Pathways | Top | |||||
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BioCyc | [+] 1 BioCyc Pathways | + | ||||
1 | Triacylglycerol biosynthesis | |||||
KEGG Pathway | [+] 4 KEGG Pathways | + | ||||
1 | Glycerolipid metabolism | |||||
2 | Retinol metabolism | |||||
3 | Metabolic pathways | |||||
4 | Fat digestion and absorption | |||||
Pathwhiz Pathway | [+] 1 Pathwhiz Pathways | + | ||||
1 | Retinol Metabolism | |||||
Reactome | [+] 2 Reactome Pathways | + | ||||
1 | Acyl chain remodeling of DAG and TAG | |||||
2 | Triglyceride Biosynthesis | |||||
WikiPathways | [+] 5 WikiPathways | + | ||||
1 | Vitamin A and Carotenoid Metabolism | |||||
2 | Statin Pathway | |||||
3 | Triacylglyceride Synthesis | |||||
4 | Glycerophospholipid biosynthesis | |||||
5 | Fatty acid, triacylglycerol, and ketone body metabolism |
References | Top | |||||
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REF 1 | Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor. J Med Chem. 2009 Mar 26;52(6):1558-68. | |||||
REF 2 | US patent application no. 7,414,033, Modulation of diacylglycerol acyltransferase 1 expression. |
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