Target Information
| Target General Information | Top | |||||
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| Target ID |
T75251
(Former ID: TTDI01923)
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| Target Name |
Tubulin receptor (TUBR)
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| Synonyms |
Tubulin protein
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| Gene Name |
NO-GeName
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| Target Type |
Clinical trial target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Retinopathy [ICD-11: 9B71] | |||||
| Function |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
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| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Clinical Trial Drug(s) | [+] 1 Clinical Trial Drugs | + | ||||
| 1 | OC-10X | Drug Info | Phase 1 | Macular degeneration | [2] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Inhibitor | [+] 1 Inhibitor drugs | + | ||||
| 1 | OC-10X | Drug Info | [1] | |||
| Target Affiliated Biological Pathways | Top | |||||
|---|---|---|---|---|---|---|
| KEGG Pathway | [+] 3 KEGG Pathways | + | ||||
| 1 | Phagosome | |||||
| 2 | Gap junction | |||||
| 3 | Pathogenic Escherichia coli infection | |||||
| Reactome | [+] 15 Reactome Pathways | + | ||||
| 1 | Translocation of GLUT4 to the plasma membrane | |||||
| 2 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | |||||
| 3 | Gap junction assembly | |||||
| 4 | MHC class II antigen presentation | |||||
| 5 | Separation of Sister Chromatids | |||||
| 6 | Resolution of Sister Chromatid Cohesion | |||||
| 7 | Recruitment of NuMA to mitotic centrosomes | |||||
| 8 | Post-chaperonin tubulin folding pathway | |||||
| 9 | Recycling pathway of L1 | |||||
| 10 | Hedgehog 'off' state | |||||
| 11 | Assembly of the primary cilium | |||||
| 12 | RHO GTPases activate IQGAPs | |||||
| 13 | RHO GTPases Activate Formins | |||||
| 14 | Mitotic Prometaphase | |||||
| 15 | Kinesins | |||||
| WikiPathways | [+] 3 WikiPathways | + | ||||
| 1 | Parkin-Ubiquitin Proteasomal System pathway | |||||
| 2 | Pathogenic Escherichia coli infection | |||||
| 3 | Protein folding | |||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01869933) Phase I Study Assessing the Ocular and Systemic Safety and Tolerability of OC-10X. U.S. National Institutes of Health. | |||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023889) | |||||
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