Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T72957
(Former ID: TTDR00426)
|
|||||
| Target Name |
Chemokine receptor (CHR)
|
|||||
| Gene Name |
NO-GeName
|
|||||
| Target Type |
Discontinued target
|
[1] | ||||
| Disease | [+] 4 Target-related Diseases | + | ||||
| 1 | Asthma [ICD-11: CA23] | |||||
| 2 | Multiple sclerosis [ICD-11: 8A40] | |||||
| 3 | Chronic obstructive pulmonary disease [ICD-11: CA22] | |||||
| 4 | Rheumatoid arthritis [ICD-11: FA20] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Discontinued Drug(s) | [+] 5 Discontinued Drugs | + | ||||
| 1 | AZD-3778 | Drug Info | Discontinued in Phase 2 | Asthma | [2], [3] | |
| 2 | AZD-4750 | Drug Info | Discontinued in Phase 1 | Multiple sclerosis | [4] | |
| 3 | AZD-7140 | Drug Info | Discontinued in Phase 1 | Rheumatoid arthritis | [5] | |
| 4 | AZD-8309 | Drug Info | Discontinued in Phase 1 | Rheumatoid arthritis | [6] | |
| 5 | AZD-0275 | Drug Info | Terminated | Rheumatoid arthritis | [7] | |
| Mode of Action | [+] 2 Modes of Action | + | ||||
| Modulator | [+] 3 Modulator drugs | + | ||||
| 1 | AZD-3778 | Drug Info | [1] | |||
| 2 | AZD-4750 | Drug Info | [8] | |||
| 3 | AZD-8309 | Drug Info | [10] | |||
| Antagonist | [+] 2 Antagonist drugs | + | ||||
| 1 | AZD-7140 | Drug Info | [9] | |||
| 2 | AZD-0275 | Drug Info | [11] | |||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | New Drugs and Targets for Asthma and COPD. Trevor T. Hansel, Peter J. Barnes. 2010. Page(304). | |||||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7679). | |||||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019934) | |||||
| REF 4 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018778) | |||||
| REF 5 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017126) | |||||
| REF 6 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017125) | |||||
| REF 7 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019127) | |||||
| REF 8 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018778) | |||||
| REF 9 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017126) | |||||
| REF 10 | CXCR2: From Bench to Bedside. Front Immunol. 2012; 3: 263. | |||||
| REF 11 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019127) | |||||
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