Target Information
| Target General Information | Top | |||||
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| Target ID |
T72478
(Former ID: TTDR00490)
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| Target Name |
Sodium/calcium exchanger (SLC)
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| Synonyms |
NaCaX; Na(+)/Ca(2+) exchanger; Mitochondrial sodium-calcium exchanger
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| Gene Name |
NO-GeName
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| Target Type |
Clinical trial target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Cardiovascular disease [ICD-11: BA00-BE2Z] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Clinical Trial Drug(s) | [+] 1 Clinical Trial Drugs | + | ||||
| 1 | CALDARET HYDRATE | Drug Info | Phase 2 | Cardiovascular disease | [1] | |
| Mode of Action | [+] 2 Modes of Action | + | ||||
| Modulator | [+] 1 Modulator drugs | + | ||||
| 1 | CALDARET HYDRATE | Drug Info | [1] | |||
| Inhibitor | [+] 1 Inhibitor drugs | + | ||||
| 1 | SEA-0400 | Drug Info | [2] | |||
| Target-Related Models and Studies | Top | |||||
|---|---|---|---|---|---|---|
| Target QSAR Model | ||||||
| References | Top | |||||
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| REF 1 | Caldaret, an intracellular Ca2+ handling modulator, limits infarct size of reperfused canine heart. J Pharmacol Sci. 2007 Feb;103(2):222-33. | |||||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4617). | |||||
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