Target Information
| Target General Information | Top | |||||
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| Target ID |
T70521
(Former ID: TTDR00591)
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| Target Name |
Bacterial MTA/SAH nucleosidase (Bact mtnN)
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| Synonyms |
mtnN; S-adenosylhomocysteine nucleosidase; P46; 5'-methylthioadenosine nucleosidase; 5'-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase
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| Gene Name |
Bact mtnN
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Can also use 5'-isobutylthioadenosine, 5'-n- butylthioadenosine, S-adenosyl-D-homocysteine, decarboxylated adenosylhomocysteine, deaminated adenosylhomocysteine and S-2-aza- adenosylhomocysteine as substrates.
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| BioChemical Class |
Glycosylase
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| UniProt ID | ||||||
| Sequence |
MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGAT
LLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFK ADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAH VCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: Adenine | Ligand Info | |||||
| Structure Description | Crystal Structure of E. coli MTA/AdoHcy Nucleosidase | PDB:1JYS | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [2] |
| PDB Sequence |
MKIGIIGAME
10 EEVTLLRDKI20 ENRQTISLGG30 CEIYTGQLNG40 TEVALLKSGI50 GKVAAALGAT 60 LLLEHCKPDV70 IINTGSAGGL80 APTLKVGDIV90 VSDEARYHDA100 DVTAFGYEYG 110 QLPGCPAGFK120 ADDKLIAAAE130 ACIAELNLNA140 VRGLIVSGDA150 FINGSVGLAK 160 IRHNFPQAIA170 VEMEATAIAH180 VCHNFNVPFV190 VVRAISDVAD200 QSFDEFLAVA 214 AKQSSLMVES224 LVQKLA
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 5'-Deoxy-5'-(Methylthio)-Tubercidin | Ligand Info | |||||
| Structure Description | Crystal structure of E. coli MTA/AdoHcy nucleosidase complexed with 5'-methylthiotubercidin (MTH) | PDB:1NC1 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [3] |
| PDB Sequence |
FSMKIGIIGA
8 MEEEVTLLRD18 KIENRQTISL28 GGCEIYTGQL38 NGTEVALLKS48 GIGKVAAALG 58 ATLLLEHCKP68 DVIINTGSAG78 GLAPTLKVGD88 IVVSDEARYH98 DADVTAFGYE 108 YGQLPGCPAG118 FKADDKLIAA128 AEACIAELNL138 NAVRGLIVSG148 DAFINGSVGL 158 AKIRHNFPQA168 IAVEMEATAI178 AHVCHNFNVP188 FVVVRAISDV198 ADQQSHLSFD 208 EFLAVAAKQS218 SLMVESLVQK228 LAHG
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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There is no similarity protein (E value < 0.005) for this target
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| Chemical Structure based Activity Landscape of Target | Top |
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| References | Top | |||||
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| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||||
| REF 2 | Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals similarity to the purine nucleoside phosphorylases. Structure. 2001 Oct;9(10):941-53. | |||||
| REF 3 | Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis. J Biol Chem. 2003 Mar 7;278(10):8761-70. | |||||
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