Target Information
| Target General Information | Top | |||||
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| Target ID |
T67754
(Former ID: TTDR00094)
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| Target Name |
Transketolase (TK)
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| Synonyms |
TKT1; SDDHD; HEL107; HEL-S-48
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| Gene Name |
TKT
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
Click to Show/Hide
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| BioChemical Class |
Transketolase
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| UniProt ID | ||||||
| EC Number |
EC 2.2.1.1
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| Sequence |
MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE LLKMFGIDRDAIAQAVRGLITKA Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| ADReCS ID | BADD_A01462 ; BADD_A05947 | |||||
| HIT2.0 ID | T47YS7 | |||||
| Chemical Structure based Activity Landscape of Target | Top |
|---|---|
| Target Poor or Non Binders | Top | |||||
|---|---|---|---|---|---|---|
| Target Poor or Non Binders | ||||||
| Target Regulators | Top | |||||
|---|---|---|---|---|---|---|
| Target-regulating microRNAs | ||||||
| Target-interacting Proteins | ||||||
| Target Affiliated Biological Pathways | Top | |||||
|---|---|---|---|---|---|---|
| BioCyc | [+] 2 BioCyc Pathways | + | ||||
| 1 | Pentose phosphate pathway | |||||
| 2 | Pentose phosphate pathway (non-oxidative branch) | |||||
| KEGG Pathway | [+] 5 KEGG Pathways | + | ||||
| 1 | Pentose phosphate pathway | |||||
| 2 | Metabolic pathways | |||||
| 3 | Biosynthesis of antibiotics | |||||
| 4 | Carbon metabolism | |||||
| 5 | Biosynthesis of amino acids | |||||
| Panther Pathway | [+] 1 Panther Pathways | + | ||||
| 1 | Pentose phosphate pathway | |||||
| Pathwhiz Pathway | [+] 2 Pathwhiz Pathways | + | ||||
| 1 | Pentose Phosphate Pathway | |||||
| 2 | Warburg Effect | |||||
| WikiPathways | [+] 3 WikiPathways | + | ||||
| 1 | Metabolism of carbohydrates | |||||
| 2 | Integration of energy metabolism | |||||
| 3 | Pentose Phosphate Pathway | |||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||||
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