Target Information
Target General Information | Top | |||||
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Target ID |
T54472
(Former ID: TTDR00299)
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Target Name |
Plasmodium CDK PfPK5 (Malaria PfPK5)
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Synonyms |
PfPK5; PK5; Cell division control protein 2 homolog; CRK2
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Gene Name |
Malaria PfPK5
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Target Type |
Literature-reported target
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[1] | ||||
Function |
It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Plays a key role in the control of the eukaryotic cell cycle.
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BioChemical Class |
Kinase
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UniProt ID | ||||||
Sequence |
MEKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHS
NIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRR VLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYST TIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTV YEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKENN Click to Show/Hide
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3D Structure | Click to Show 3D Structure of This Target | PDB |
References | Top | |||||
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REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
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