Target Information
| Target General Information | Top | |||||
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| Target ID |
T52501
(Former ID: TTDR01432)
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| Target Name |
MEKK2 messenger RNA (MAP3K2 mRNA)
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| Synonyms |
Mitogen-activated protein kinase kinase kinase 2 (mRNA); MEKK2 (mRNA); MEKK 2 (mRNA); MEK kinase 2 (mRNA); MAPKKK2 (mRNA)
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| Gene Name |
MAP3K2
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics. Component of a protein kinase signal transduction cascade.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| EC Number |
EC 2.7.11.25
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| Sequence |
MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFP
RPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLV INGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARN GSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSY PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVE AKLRPSADELLRHMFVHYH Click to Show/Hide
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| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Target Affiliated Biological Pathways | Top | |||||
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| KEGG Pathway | [+] 3 KEGG Pathways | + | ||||
| 1 | MAPK signaling pathway | |||||
| 2 | Gap junction | |||||
| 3 | GnRH signaling pathway | |||||
| NetPath Pathway | [+] 3 NetPath Pathways | + | ||||
| 1 | IL5 Signaling Pathway | |||||
| 2 | TGF_beta_Receptor Signaling Pathway | |||||
| 3 | TCR Signaling Pathway | |||||
| Panther Pathway | [+] 3 Panther Pathways | + | ||||
| 1 | B cell activation | |||||
| 2 | EGF receptor signaling pathway | |||||
| 3 | FGF signaling pathway | |||||
| PID Pathway | [+] 2 PID Pathways | + | ||||
| 1 | ErbB1 downstream signaling | |||||
| 2 | Trk receptor signaling mediated by the MAPK pathway | |||||
| WikiPathways | [+] 6 WikiPathways | + | ||||
| 1 | Insulin Signaling | |||||
| 2 | EGF/EGFR Signaling Pathway | |||||
| 3 | MAPK Cascade | |||||
| 4 | MAPK Signaling Pathway | |||||
| 5 | BDNF signaling pathway | |||||
| 6 | IL-1 signaling pathway | |||||
| References | Top | |||||
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| REF 1 | US patent application no. 6,287,860, Antisense inhibition of MEKK2 expression. | |||||
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