Target Information

Target General Information

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Target ID

T36467 (Former ID: TTDI02014)

Target Name

Cytosine deaminase (AICDA)

Synonyms

Activationinduced cytidine deaminase; AICDA

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Gene Name

AICDA

Target Type

Clinical trial target

[1]

Disease

[+] 1 Target-related Diseases

Solid tumour/cancer [ICD-11: 2A00-2F9Z]

Function

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

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BioChemical Class

Carbon-nitrogen hydrolase

UniProt ID

AICDA_HUMAN

EC Number

EC 3.5.4.38

Sequence

MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELL
FLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRK
AEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRIL
LPLYEVDDLRDAFRTLGL

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3D Structure

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PDB

Drugs and Modes of Action

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Clinical Trial Drug(s)

[+] 1 Clinical Trial Drugs

JX-929

Drug Info

Phase 1

Solid tumour/cancer

[2]

Mode of Action

[+] 1 Modes of Action

Modulator

[+] 1 Modulator drugs

JX-929

Drug Info

[1]

Cell-based Target Expression Variations

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Cell-based Target Expression Variations

Cell-based Target Expression Variations Info

Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function. Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006). Human Similarity Proteins Human Pathway Affiliation

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.

Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).

Human Similarity Proteins

Human Pathway Affiliation

Protein Name	Pfam ID	Percentage of Identity (%)	E value
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G)	PF18782	44.865 (83/185)	1.86E-42
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)	PF18782	44.253 (77/174)	2.50E-41
DNA dC->dU-editing enzyme APOBEC-3A (APOBEC3A)	PF18782	42.553 (80/188)	7.36E-41
DNA dC->dU-editing enzyme APOBEC-3F (APOBEC3F)	PF18782	42.458 (76/179)	3.49E-40
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)	PF18782	42.553 (80/188)	7.11E-38
DNA dC->dU-editing enzyme APOBEC-3H (APOBEC3H)	PF18771	35.106 (66/188)	3.55E-29
C->U-editing enzyme APOBEC-1 (APOBEC1)	PF18774	34.921 (44/126)	8.51E-20
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KEGG Pathway	Pathway ID	Affiliated Target	Pathway Map
Intestinal immune network for IgA production	hsa04672	Affiliated Target
Class: Organismal Systems => Immune system	Pathway Hierarchy

Target Affiliated Biological Pathways

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KEGG Pathway

[+] 2 KEGG Pathways

Intestinal immune network for IgA production

Primary immunodeficiency

NetPath Pathway

[+] 2 NetPath Pathways

IL4 Signaling Pathway

ID Signaling Pathway

PID Pathway

[+] 1 PID Pathways

IL4-mediated signaling events

References

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REF 1

Micromanaging oncolytic viruses. SciBX 1(42); doi:10.1038/scibx.2008.1014. Nov. 20 2008

REF 2

ClinicalTrials.gov (NCT00574977) Safety Study of Modified Vaccinia Virus to Cancer. U.S. National Institutes of Health.

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