Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T32862
|
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| Target Name |
Fungal Cell membrane ergosterol (Fung CME)
|
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| Gene Name |
NO-GeName
|
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| Target Type |
Successful target
|
[1] | ||||
| Disease | [+] 2 Target-related Diseases | + | ||||
| 1 | Bacterial infection [ICD-11: 1A00-1C4Z] | |||||
| 2 | Fungal infection [ICD-11: 1F29-1F2F] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Approved Drug(s) | [+] 3 Approved Drugs | + | ||||
| 1 | Amphotericin B | Drug Info | Approved | Fungal infection | [2] | |
| 2 | Candicidin | Drug Info | Approved | Bacterial infection | [3] | |
| 3 | Nystatin | Drug Info | Approved | Fungal infection | [4] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Modulator | [+] 3 Modulator drugs | + | ||||
| 1 | Amphotericin B | Drug Info | [1] | |||
| 2 | Candicidin | Drug Info | [5] | |||
| 3 | Nystatin | Drug Info | [6] | |||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels. Biochim Biophys Acta. 2002 Dec 23;1567(1-2):63-78. | |||||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 050724. | |||||
| REF 3 | Drug information of Candicidin, 2008. eduDrugs. | |||||
| REF 4 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 062124. | |||||
| REF 5 | Mode of Action of the Polyene Antibiotic Candicidin: Binding Factors in the Wall of Candida albicans | |||||
| REF 6 | Cholesterol and Ergosterol Influence Nystatin Surface Aggregation: Relation to Pore Formation | |||||
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