The residues interacting with the ligand at a distance of less than 5Å were defined as the drug binding pocket and labelled in ORANGE (Nat Commun. 14: 2175, 2023).

(1) The residues interacting with the ligand at a distance of less than 5Å were defined as the drug binding pocket and provided below (Nat Commun. 14: 2175, 2023).

(2) H-bonding was determined by a distance of less than 3.5 Å and the distances within 3.5 Å were underlined (J Am Chem Soc. 142: 14150-14157, 2020).