Target Information

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Target General Information
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
References
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
Protein Name Pfam ID Percentage of Identity (%) E value
Mixed lineage kinase 1 (MAP3K9)
PF00069 ; 
PF14604
32.734 (91/278) 2.40E-31
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
PF00069 ; 
PF12721
31.321 (83/265) 4.63E-23
Serine/threonine-protein kinase 24 (STK24)
PF00069
29.183 (75/257) 8.71E-23
Unc-51 like kinase 3 (ULK3)
PF04212 ; 
PF00069
27.481 (72/262) 2.21E-22
Serine/threonine-protein kinase 33 (STK33)
PF00069
30.973 (70/226) 1.66E-21
Omphalocele kinase 1 (NUAK1)
PF00069
30.631 (68/222) 2.86E-21
Serine/threonine-protein kinase 26 (STK26)
PF00069
29.249 (74/253) 8.85E-21
Serine/threonine-protein kinase 25 (STK25)
PF00069
29.057 (77/265) 1.78E-20
NUAK family SNF1-like kinase 2 (NUAK2)
PF00069
29.596 (66/223) 2.12E-20
MST-1 protein kinase (STK4)
PF11629 ; 
PF00069
30.846 (62/201) 2.66E-20
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
PF16579 ; 
PF00069
26.923 (70/260) 4.16E-20
Fused homolog (STK36)
PF13646 ; 
PF00069
29.536 (70/237) 4.22E-20
Cyclin-dependent kinase 7 (CDK7)
PF00069
29.442 (58/197) 3.91E-19
Serine/threonine-protein kinase 3 (STK3)
PF11629 ; 
PF00069
27.599 (77/279) 4.25E-19
Serine/threonine-protein kinase Nek4 (NEK4)
PF00069
28.309 (77/272) 7.38E-19
BR serine/threonine kinase 2 (BRSK2)
PF00069
25.385 (66/260) 8.98E-19
PKC-delta-interacting protein kinase (RIPK4)
PF12796 ; 
PF00069
31.930 (91/285) 2.03E-18
Putative serine/threonine-protein kinase SIK1B (SIK1B)
PF00069
26.259 (73/278) 2.97E-18
Salt-inducible kinase 1 (SIK1)
PF00069
26.259 (73/278) 3.00E-18
Cyclin-dependent kinase 3 (CDK3)
PF00069
28.205 (55/195) 3.01E-18
STE20-related serine/threonine-protein kinase (SLK)
PF00069 ; 
PF12474
27.547 (73/265) 3.89E-18
Cyclin-dependent kinase 2 (CDK2)
PF00069
28.205 (55/195) 1.19E-17
Serine/threonine-protein kinase Nek3 (NEK3)
PF00069
24.701 (62/251) 1.41E-17
SIK family kinase 3 (SIK3)
PF00069
28.194 (64/227) 3.81E-17
Ribosomal protein S6 kinase alpha-2 (RSK2)
PF00069 ; 
PF00433
27.679 (62/224) 5.22E-17
Serine/threonine-protein kinase Nek8 (NEK8)
PF00069 ; 
PF00415
24.000 (66/275) 7.31E-17
NIMA-related kinase 7 (NEK7)
PF00069
24.125 (62/257) 1.64E-16
Cyclin-dependent kinase 13 (CDK13)
PF12330 ; 
PF00069
26.042 (75/288) 1.71E-16
NIMA-related kinase 6 (NEK6)
PF00069
23.529 (64/272) 1.74E-16
Serine/threonine-protein kinase Nek11 (NEK11)
PF00069
27.200 (68/250) 1.76E-16
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
PF16579 ; 
PF00069
26.457 (59/223) 1.78E-16
Polo-like kinase 4 (PLK4)
PF00069 ; 
PF18190 ; 
PF18409
More >>
 27.391 (63/230) 1.96E-16
Serine/threonine-protein kinase NIM1 (NIM1K)
PF00069
28.448 (66/232) 2.22E-16
Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G)
PF00069
26.606 (58/218) 2.81E-16
Cyclin-dependent kinase 5 (CDK5)
PF00069
26.396 (52/197) 4.38E-16
Serine/threonine-protein kinase MARK2 (MARK2)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 27.149 (60/221) 4.43E-16
Salt-inducible kinase 2 (SIK2)
PF00069
28.431 (58/204) 4.66E-16
Serine/threonine-protein kinase 10 (STK10)
PF00069 ; 
PF12474
25.896 (65/251) 4.74E-16
MAP/microtubule affinity-regulating kinase 4 (MARK4)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 26.697 (59/221) 5.66E-16
Ribosomal protein S6 kinase alpha-3 (RSK3)
PF00069 ; 
PF00433
27.111 (61/225) 6.69E-16
Myosin light chain kinase 3 (MYLK3)
PF00069
28.241 (61/216) 8.52E-16
IL-1 receptor-associated kinase 3 (IRAK3)
PF00531 ; 
PF00069
26.582 (84/316) 1.00E-15
Serine/threonine-protein kinase PAK 6 (PAK6)
PF00786 ; 
PF00069
26.840 (62/231) 1.05E-15
Ribosomal protein S6 kinase alpha-6 (RSK6)
PF00069 ; 
PF00433
28.000 (63/225) 1.06E-15
Serine/threonine-protein kinase TAO2 (TAOK2)
PF00069
27.632 (63/228) 1.19E-15
BR serine/threonine kinase 1 (BRSK1)
PF00069
23.552 (61/259) 1.21E-15
Microtubule affinity regulating kinase 3 (MARK3)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 26.556 (64/241) 1.60E-15
TRAF2 and NCK interacting kinase (TNIK)
PF00780 ; 
PF00069
25.418 (76/299) 1.94E-15
Cyclin-dependent kinase 12 (CDK12)
PF00069
25.592 (54/211) 4.46E-15
ERK activator kinase 5 (MAP2K5)
PF00564 ; 
PF00069
27.413 (71/259) 5.10E-15
Cyclin-dependent kinase-like 1 (CDKL1)
PF00069
28.571 (56/196) 5.26E-15
Ribosomal protein S6 kinase alpha-1 (RSK1)
PF00069 ; 
PF00433
25.000 (57/228) 6.46E-15
Serine/threonine-protein kinase PAK 5 (PAK5)
PF00786 ; 
PF00069
26.667 (64/240) 7.03E-15
Serine/threonine-protein kinase ULK2 (ULK2)
PF12063 ; 
PF00069
25.217 (58/230) 7.58E-15
Hormonally up-regulated neu tumor-associated kinase (HUNK)
PF00069
24.242 (64/264) 7.61E-15
Serine/threonine-protein kinase D2 (PRKD2)
PF00130 ; 
PF00069
24.324 (63/259) 8.59E-15
IL-1 receptor-associated kinase 1 (IRAK1)
PF00531 ; 
PF00069
26.522 (61/230) 8.71E-15
Serine/threonine-protein kinase D3 (PRKD3)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 26.201 (60/229) 9.27E-15
Cyclin-dependent kinase 1 (CDK1)
PF00069
26.923 (56/208) 1.12E-14
Cyclin-dependent kinase 6 (CDK6)
PF00069
26.923 (63/234) 1.17E-14
Serine/threonine-protein kinase Nek5 (NEK5)
PF00069
24.766 (53/214) 1.24E-14
Serine/threonine-protein kinase PLK3 (PLK3)
PF00069 ; 
PF00659
26.316 (65/247) 1.53E-14
Extracellular signal-regulated kinase 2 (ERK2)
PF00069
29.064 (59/203) 1.53E-14
TAO kinase 1 (TAOK1)
PF00069
27.632 (63/228) 1.78E-14
Protein kinase D (PRKD1)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 25.664 (58/226) 1.81E-14
Tyrosine-protein kinase EIF2AK2 (p68)
PF00035 ; 
PF00069
24.017 (55/229) 1.84E-14
Serine/threonine-protein kinase MARK1 (MARK1)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 26.244 (58/221) 1.93E-14
Cyclin-dependent kinase 15 (CDK15)
PF00069
23.438 (45/192) 2.05E-14
Cyclin-dependent kinase 10 (CDK10)
PF00069
28.934 (57/197) 3.05E-14
Polo-like kinase 2 (PLK2)
PF00069 ; 
PF00659
24.303 (61/251) 3.33E-14
Cyclin-dependent kinase-like 3 (CDKL3)
PF00069
28.646 (55/192) 3.89E-14
Aurora kinase C (AURKC)
PF00069
23.846 (62/260) 4.19E-14
Serine/threonine-protein kinase ULK1 (ULK1)
PF12063 ; 
PF00069
23.929 (67/280) 5.78E-14
Extracellular signal-regulated kinase 1 (ERK1)
PF00069
28.358 (57/201) 6.27E-14
Misshapen-like kinase 1 (MINK1)
PF00780 ; 
PF00069
27.099 (71/262) 7.29E-14
Cyclin-dependent kinase-like 2 (CDKL2)
PF00069
28.141 (56/199) 7.40E-14
Ste-20-related kinase (STK39)
PF12202 ; 
PF00069
24.723 (67/271) 9.20E-14
Death-associated protein kinase 1 (DAPK1)
PF00023 ; 
PF12796 ; 
PF13637 ; 
PF00531 ; 
PF00069
More >>
 26.943 (52/193) 1.02E-13
PAK-4 protein kinase (PAK4)
PF00786 ; 
PF00069
27.397 (60/219) 1.11E-13
Cyclin-dependent kinase-like 5 (CDKL5)
PF00069
24.352 (47/193) 1.22E-13
Mitogen-activated protein kinase 15 (MAPK15)
PF00069
29.500 (59/200) 1.40E-13
Death-associated protein kinase 3 (DAPK3)
PF00069
25.114 (55/219) 1.46E-13
Leucine-rich repeat kinase 2 (LRRK2)
PF16095 ; 
PF12799 ; 
PF13855 ; 
PF00069 ; 
PF08477
More >>
 26.172 (67/256) 1.54E-13
Death-associated protein kinase 2 (DAPK2)
PF00069
28.571 (50/175) 2.62E-13
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)
PF00069
25.203 (62/246) 2.76E-13
Cyclin-dependent kinase-like 4 (CDKL4)
PF00069
24.742 (48/194) 2.83E-13
TAO kinase 3 (TAOK3)
PF00069
29.384 (62/211) 2.93E-13
MEK kinase kinase 4 (MAP4K4)
PF00780 ; 
PF00069
25.676 (76/296) 3.02E-13
Proto-oncogene serine/threonine-protein kinase mos (MOS)
PF00069
26.207 (76/290) 3.13E-13
WNK lysine-deficient protein kinase 3 (WNK3)
PF12202 ; 
PF00069
25.185 (68/270) 3.47E-13
Serine/threonine-protein kinase tousled-like 2 (TLK2)
PF00069
25.547 (70/274) 3.81E-13
Cyclin-dependent kinase 14 (CDK14)
PF00069
23.316 (45/193) 4.62E-13
Serine/threonine-protein kinase tousled-like 1 (TLK1)
PF00069
23.567 (74/314) 4.77E-13
Putative serine/threonine-protein kinase PRKY (PRKY)
PF00069
25.806 (56/217) 4.82E-13
Cyclin-dependent kinase 11A (CDK11A)
PF00069
28.000 (56/200) 5.14E-13
Testis-specific serine/threonine-protein kinase 6 (TSSK6)
PF00069
27.799 (72/259) 5.15E-13
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
PF00069
25.000 (55/220) 5.43E-13
Serine/threonine-protein kinase ICK (CILK1)
PF00069
24.615 (48/195) 6.56E-13
Ribosomal protein S6 kinase beta-1 (S6K1)
PF00069 ; 
PF00433
25.402 (79/311) 7.21E-13
Cyclin-dependent kinase 17 (CDK17)
PF12330 ; 
PF00069
24.227 (47/194) 7.24E-13
SPS1/STE20-related protein kinase YSK4 (YSK4)
PF00069
25.475 (67/263) 8.18E-13
Cyclin-dependent kinase 16 (CDK16)
PF12330 ; 
PF00069
23.958 (46/192) 8.22E-13
Inhibitor of nuclear factor kappa-B kinase beta (IKKB)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 26.786 (60/224) 1.11E-12
Serine/threonine-protein kinase WNK4 (WNK4)
PF12202 ; 
PF00069
26.449 (73/276) 1.13E-12
Serine/threonine-protein kinase NLK (NLK)
PF00069
26.866 (54/201) 1.30E-12
Serine/threonine-protein kinase PAK 3 (PAK3)
PF00786 ; 
PF00069
22.857 (72/315) 1.31E-12
Extracellular signal-regulated kinase 5 (ERK5)
PF00069
25.571 (56/219) 1.33E-12
Cyclin-dependent kinase 11B (CDK11B)
PF00069
28.000 (56/200) 1.39E-12
MAPK/MAK/MRK overlapping kinase (MOK)
PF00069
29.851 (60/201) 1.53E-12
ERK activator kinase 7 (MAP2K7)
PF00069
25.191 (66/262) 1.56E-12
Serine/threonine-protein kinase MAK (MAK)
PF00069
25.389 (49/193) 1.87E-12
Maternal embryonic leucine zipper kinase (MELK)
PF02149 ; 
PF00069
25.794 (65/252) 1.90E-12
Mitogen-activated protein kinase kinase kinase 15 (MAP3K15)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 28.502 (59/207) 1.96E-12
Apoptosis signal-regulating kinase 2 (MAP3K6)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 26.432 (60/227) 1.96E-12
Cyclin-dependent kinase 20 (CDK20)
PF00069
28.426 (56/197) 2.05E-12
Polo-like kinase 1 (PLK1)
PF00069 ; 
PF00659
25.366 (52/205) 2.25E-12
Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1)
PF12796 ; 
PF16095 ; 
PF00069 ; 
PF08477
More >>
 27.039 (63/233) 2.34E-12
TGF-beta receptor type I (TGFBR1)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 25.062 (101/403) 4.49E-12
Serine/threonine-protein kinase WNK1 (WNK1)
PF12202 ; 
PF00069
25.763 (76/295) 4.69E-12
Doublecortin-like kinase 1 (DCLK1)
PF03607 ; 
PF00069
27.731 (66/238) 5.63E-12
Cyclin-dependent kinase 4 (CDK4)
PF00069
28.750 (69/240) 6.59E-12
Ribosomal protein S6 kinase beta-2 (RPS6KB2)
PF00069 ; 
PF00433
24.595 (76/309) 7.22E-12
Titin (TTN) 26.840 (62/231) 7.59E-12
Putative 3-phosphoinositide-dependent protein kinase 2 (PDPK2P)
PF00069
21.711 (66/304) 7.87E-12
TGF-beta-stimulated factor 1 (STK16)
PF00069
24.675 (57/231) 8.45E-12
Oxidative stress responsive 1 (OXSR1)
PF12202 ; 
PF00069
22.800 (57/250) 9.03E-12
PAK-1 protein kinase (PAK1)
PF00786 ; 
PF00069
23.308 (62/266) 1.16E-11
ERK activator kinase 2 (MEK2)
PF00069
29.012 (47/162) 1.18E-11
Aurora kinase A (AURKA)
PF00069
25.561 (57/223) 1.21E-11
MAPK-activated protein kinase 3 (MAPKAPK3)
PF00069
25.217 (58/230) 1.23E-11
Apoptosis signal-regulating kinase 1 (MAP3K5)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 28.708 (60/209) 1.25E-11
SNF-related serine/threonine-protein kinase (SNRK)
PF00069
22.868 (59/258) 1.26E-11
MAPK/ERK kinase kinase 4 (MAP3K4)
PF19431 ; 
PF00069
25.368 (69/272) 1.37E-11
Myosin-IIIb (MYO3B)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 27.018 (77/285) 1.42E-11
Protein kinase C theta (PRKCQ)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 21.659 (47/217) 1.50E-11
Serine/threonine-protein kinase 17B (STK17B)
PF00069
26.009 (58/223) 1.52E-11
Aurora kinase B (AURKB)
PF00069
24.206 (61/252) 1.63E-11
PAK-2 protein kinase (PAK2)
PF00786 ; 
PF00069
22.642 (60/265) 2.26E-11
Cytoplasmic DRAK1 (STK17A)
PF00069
25.309 (41/162) 2.50E-11
Testis-specific serine kinase 2 (TSSK2)
PF00069
25.368 (69/272) 3.19E-11
Activin receptor type IB (ACVR1B)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 24.837 (76/306) 3.29E-11
Myosin-IIIa (MYO3A)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 25.623 (72/281) 3.37E-11
Cyclin-dependent kinase 18 (CDK18)
PF00069
23.737 (47/198) 3.59E-11
Phosphorylase kinase testis gamma 2 (PHKG2)
PF00069
24.901 (63/253) 3.74E-11
ERK activator kinase 1 (MEK1)
PF00069
27.273 (42/154) 4.55E-11
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
PF00069
23.881 (64/268) 5.44E-11
Cyclin-dependent kinase 9 (CDK9)
PF00069
25.373 (51/201) 5.51E-11
Doublecortin-like kinase 2 (DCLK2)
PF03607 ; 
PF00069
25.818 (71/275) 6.29E-11
NIMA-related kinase 1 (NEK1)
PF00069
22.261 (63/283) 6.60E-11
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1)
PF00069
26.000 (65/250) 7.25E-11
Testis-specific serine/threonine-protein kinase 1 (TSSK1B)
PF00069
24.151 (64/265) 7.64E-11
Phosphoinositide dependent protein kinase-1 (PDPK1)
PF14593 ; 
PF00069
22.335 (44/197) 7.65E-11
Myosin light chain kinase family member 4 (MYLK4)
PF00069
22.936 (50/218) 9.01E-11
Serine/threonine-protein kinase STK11 (STK11)
PF00069
23.529 (64/272) 1.04E-10
Serine/threonine-protein kinase WNK2 (WNK2)
PF12202 ; 
PF00069
27.313 (62/227) 1.13E-10
Serine/threonine-protein kinase H2 (PSKH2)
PF00069
25.424 (60/236) 1.85E-10
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 25.974 (60/231) 1.86E-10
Doublecortin-like kinase 3 (DCLK3)
PF00069
26.638 (61/229) 2.02E-10
Ribosomal protein S6 kinase alpha-5 (RSK5)
PF00069 ; 
PF00433
25.862 (45/174) 2.11E-10
Protein kinase N1 (PKN1)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 26.710 (82/307) 2.59E-10
Serine/threonine-protein kinase Nek9 (NEK9)
PF00069 ; 
PF00415
24.506 (62/253) 2.65E-10
MAPK/ERK kinase kinase 1 (MAP3K1)
PF00069
25.822 (55/213) 3.01E-10
MEK kinase kinase 1 (MAP4K1)
PF00780 ; 
PF00069
22.878 (62/271) 3.07E-10
Cyclin-dependent kinase 19 (CDK19)
PF00069
26.291 (56/213) 3.11E-10
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
PF00069
24.715 (65/263) 3.27E-10
Peripheral plasma membrane protein CASK (CASK)
PF00625 ; 
PF02828 ; 
PF00595 ; 
PF00069 ; 
PF00018
More >>
 25.991 (59/227) 3.32E-10
Bone morphogenetic protein receptor (BMPR2)
PF01064 ; 
PF00069
24.771 (81/327) 3.93E-10
MAPK/ERK kinase kinase 3 (MAP3K3)
PF00564 ; 
PF00069
24.528 (65/265) 4.53E-10
Serine/threonine-protein kinase 32A (STK32A)
PF00069
24.000 (54/225) 5.27E-10
Myosin light chain kinase 2 (MYLK2)
PF00069
24.074 (52/216) 6.33E-10
Serine/threonine-protein kinase Chk2 (RAD53)
PF00498 ; 
PF00069
24.771 (81/327) 6.63E-10
Calcium/calmodulin-dependent protein kinase type 1B (PNCK)
PF00069
25.769 (67/260) 7.75E-10
Protein kinase C delta (PRKCD)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 23.182 (51/220) 7.89E-10
TBC domain-containing protein kinase-like protein (TBCK)
PF00069 ; 
PF00566 ; 
PF00581
More >>
 25.541 (59/231) 9.02E-10
RAC-gamma serine/threonine-protein kinase (AKT3)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 24.413 (52/213) 1.10E-09
Protein kinase G1 (PRKG1)
PF00027 ; 
PF16808 ; 
PF00069
More >>
 27.404 (57/208) 1.23E-09
Citron Rho-interacting kinase (CIT)
PF00780 ; 
PF00169 ; 
PF00069
More >>
 23.293 (58/249) 1.28E-09
Microtubule-associated serine/threonine-protein kinase 3 (MAST3)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 23.377 (54/231) 1.40E-09
NF-kappa-B-activating kinase (TBK1)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 26.050 (62/238) 1.58E-09
Protein kinase C gamma (PRKCG)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 30.841 (33/107) 1.59E-09
Serine/threonine-protein kinase Sgk2 (SGK2)
PF00069 ; 
PF00433
23.832 (51/214) 1.68E-09
Inhibitor of nuclear factor kappa-B kinase alpha (IKKA)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 25.701 (55/214) 1.71E-09
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)
PF08332 ; 
PF00069
24.017 (55/229) 1.75E-09
MEK kinase kinase 3 (MAP4K3)
PF00780 ; 
PF00069
26.425 (51/193) 1.83E-09
NIMA-related kinase 2 (NEK2)
PF00069
23.333 (63/270) 1.90E-09
Serine/threonine-protein kinase Sgk1 (SGK1)
PF00069 ; 
PF00433
23.129 (68/294) 1.94E-09
Serine/threonine-protein kinase Sgk3 (SGK3)
PF00069 ; 
PF00433 ; 
PF00787
More >>
 26.733 (54/202) 2.16E-09
Stress-activated protein kinase 2b (p38 beta)
PF00069
25.854 (53/205) 2.46E-09
Striated muscle preferentially expressed protein kinase (SPEG)
PF07679 ; 
PF00069 ; 
PF16650
More >>
 25.439 (58/228) 2.67E-09
Protein kinase C epsilon (PRKCE)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 23.364 (50/214) 2.83E-09
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)
PF00069
23.208 (68/293) 3.03E-09
Stress-activated protein kinase 2a (p38 alpha)
PF00069
25.949 (41/158) 3.29E-09
Serine/threonine-protein kinase MRCK gamma (CDC42BPG)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF00069
More >>
 24.242 (64/264) 3.36E-09
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)
PF00069
22.177 (55/248) 3.37E-09
MAPK-activated protein kinase 2 (MAPKAPK2)
PF00069
26.027 (38/146) 3.44E-09
Checkpoint kinase-1 (CHK1)
PF00069
26.636 (57/214) 3.63E-09
MEK kinase kinase 2 (MAP4K2)
PF00780 ; 
PF00069
24.870 (48/193) 4.63E-09
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)
PF00531 ; 
PF00069
26.693 (67/251) 5.35E-09
MAP kinase p38 (MAPK12)
PF00069
26.452 (41/155) 5.39E-09
Endoplasmic reticulum to nucleus signaling 1 (ERN1)
PF00069 ; 
PF06479
27.103 (58/214) 7.12E-09
Nik-related protein kinase (NRK)
PF00780 ; 
PF00069
24.576 (58/236) 7.99E-09
Activin receptor type IIA (ACVR2A)
PF01064 ; 
PF00069
25.000 (53/212) 8.26E-09
Testis-specific serine/threonine-protein kinase 4 (TSSK4)
PF00069
21.162 (51/241) 9.34E-09
Calmodulin-dependent kinase II (CAMKK2)
PF00069
24.118 (41/170) 9.55E-09
Yet another novel kinase 2 (STK32B)
PF00069
21.973 (49/223) 9.70E-09
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
PF00069
23.759 (67/282) 1.15E-08
MAPK/ERK kinase kinase 2 (MAP3K2)
PF00564 ; 
PF00069
25.373 (51/201) 1.49E-08
Microtubule-associated serine/threonine-protein kinase 1 (MAST1)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 22.650 (53/234) 1.58E-08
Serine/threonine-protein kinase SBK1 (SBK1)
PF00069
25.703 (64/249) 1.59E-08
RAC-alpha serine/threonine-protein kinase (AKT1)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 26.267 (57/217) 1.61E-08
Protein kinase N3 (PKN3)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 26.697 (59/221) 1.87E-08
Stress-activated protein kinase JNK1 (JNK1)
PF00069
28.846 (45/156) 1.95E-08
Stress-activated protein kinase JNK3 (JNK3)
PF00069
28.205 (44/156) 2.13E-08
Protein kinase C alpha (PRKCA)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 24.786 (58/234) 2.47E-08
CDC42 binding protein kinase alpha (DMPK-like alpha)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069 ; 
PF00433
More >>
 25.121 (52/207) 2.65E-08
Activin receptor type IIB (ACVR2B)
PF01064 ; 
PF00069
23.361 (57/244) 2.74E-08
RAC-beta serine/threonine-protein kinase (AKT2)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 22.535 (48/213) 2.90E-08
Microtubule-associated serine/threonine-protein kinase 2 (MAST2)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 22.511 (52/231) 3.03E-08
Microtubule-associated serine/threonine-protein kinase 4 (MAST4)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 23.301 (48/206) 3.45E-08
STE20-related kinase adapter protein alpha (STRADA)
PF00069
23.661 (53/224) 3.54E-08
Protein kinase C beta (PRKCB)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 23.207 (55/237) 3.85E-08
Serine/threonine-protein kinase H1 (PSKH1)
PF00069
22.979 (54/235) 3.96E-08
Mitogen-activated protein kinase 13 (MAPK13)
PF00069
25.616 (52/203) 4.40E-08
Serine/threonine-protein kinase Nek10 (NEK10)
PF00069
21.269 (57/268) 4.42E-08
Cyclin-dependent kinase 8 (CDK8)
PF00069
25.822 (55/213) 5.47E-08
PAS domain-containing serine/threonine-protein kinase (PASK)
PF13426 ; 
PF00069
22.381 (47/210) 6.10E-08
Serine/threonine-protein kinase/endoribonuclease IRE2 (ERN2)
PF00069 ; 
PF06479
26.923 (84/312) 6.33E-08
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
PF00069
24.101 (67/278) 6.50E-08
Serine/threonine-protein kinase pim-2 (PIM2)
PF00069
27.083 (78/288) 8.75E-08
Testis-specific serine/threonine-protein kinase 3 (TSSK3)
PF00069
24.806 (64/258) 9.73E-08
MAP kinase signal-integrating kinase 2 (MKNK2)
PF00069
23.246 (53/228) 1.41E-07
Protein kinase N2 (PKN2)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 26.339 (59/224) 1.43E-07
Protein kinase G2 (PRKG2)
PF00027 ; 
PF00069
23.556 (53/225) 1.51E-07
cAMP-dependent protein kinase catalytic subunit gamma (PRKACG)
PF00069
22.277 (45/202) 1.52E-07
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)
PF08332 ; 
PF00069
24.000 (54/225) 1.60E-07
Serine/threonine-protein kinase 32C (STK32C)
PF00069
21.963 (47/214) 1.72E-07
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)
PF00069
27.326 (47/172) 1.76E-07
Serine/threonine-protein kinase NIK (MAP3K14)
PF00069
25.581 (55/215) 2.40E-07
Ribosomal protein S6 kinase alpha-4 (RPS6KA4)
PF00069 ; 
PF00433
26.012 (45/173) 2.57E-07
G protein-coupled receptor kinase 6 (GRK6)
PF00069 ; 
PF00615
21.028 (45/214) 2.92E-07
Serine/threonine-protein kinase MRCK beta (CDC42BPB)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069
More >>
 22.944 (53/231) 3.30E-07
Calcium/calmodulin-dependent protein kinase type IV (CAMK4)
PF00069
25.333 (57/225) 3.79E-07
Serine/threonine-protein kinase pim-1 (PIM1)
PF00069
24.911 (70/281) 4.07E-07
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)
PF08332 ; 
PF00069
23.605 (55/233) 4.57E-07
Protein kinase C iota (PRKCI)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 24.510 (50/204) 4.77E-07
Stress-activated protein kinase JNK2 (JNK2)
PF00069
27.673 (44/159) 4.88E-07
Homeodomain-interacting protein kinase 4 (HIPK4)
PF00069
26.056 (74/284) 6.32E-07
Protein kinase C eta type (PRKCH)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 21.498 (66/307) 6.58E-07
STE20-related kinase adapter protein beta (STRADB)
PF00069
24.571 (43/175) 8.40E-07
Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3)
PF00069
23.246 (53/228) 1.04E-06
Ribosomal protein S6 kinase-related protein (RSKR)
PF00069
23.669 (40/169) 1.05E-06
Triple functional domain protein (TRIO)
PF00650 ; 
PF07679 ; 
PF00169 ; 
PF00069 ; 
PF00621 ; 
PF16609 ; 
PF00018 ; 
PF00435
More >>
 27.485 (47/171) 1.19E-06
Protein kinase C zeta (PRKCZ)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 21.236 (55/259) 1.35E-06
Membrane-associated kinase (PKMYT1)
PF00069
26.718 (70/262) 1.53E-06
G protein-coupled receptor kinase 5 (GRK5)
PF00069 ; 
PF00615
22.927 (47/205) 1.77E-06
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)
PF00780 ; 
PF00069
23.316 (45/193) 2.12E-06
CaM kinase-like vesicle-associated protein (CAMKV)
PF00069
25.701 (55/214) 2.26E-06
Serine/threonine-protein kinase 35 (STK35)
PF00069
23.404 (33/141) 2.31E-06
Serine/threonine-protein kinase greatwall (MASTL)
PF00069
24.161 (36/149) 3.14E-06
Serine/threonine kinase-like domain-containing protein STKLD1 (STKLD1)
PF00069
28.421 (27/95) 3.27E-06
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)
PF08332 ; 
PF00069
23.333 (56/240) 3.65E-06
Serine/threonine-protein kinase SBK2 (SBK2)
PF00069
28.218 (57/202) 4.03E-06
CaM-kinase IV kinase (CAMKK1)
PF00069
22.289 (37/166) 4.14E-06
Serine/threonine-protein kinase PDIK1L (PDIK1L)
PF00069
20.866 (53/254) 4.57E-06
Serine/threonine-protein kinase Kist (UHMK1)
PF00069 ; 
PF00076
27.604 (53/192) 5.63E-06
Wee1-like protein kinase 2 (WEE2)
PF00069
28.148 (38/135) 6.67E-06
PIM-3 protein kinase (PIM3)
PF00069
25.448 (71/279) 7.92E-06
Homeodomain-interacting protein kinase 3 (HIPK3)
PF00069
26.341 (54/205) 8.40E-06
Sugen kinase 110 (SBK3)
PF00069
27.922 (43/154) 1.06E-05
Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B)
PF00069
22.997 (66/287) 1.15E-05
Rhodopsin kinase GRK1 (GRK1)
PF00069 ; 
PF00615
20.197 (41/203) 1.23E-05
Glycogen synthase kinase-3 beta (GSK-3B)
PF00069
24.752 (50/202) 2.20E-05
PDZ binding kinase (PBK)
PF00069
20.930 (36/172) 2.56E-05
PRKR-like endoplasmic reticulum kinase (PERK)
PF00069
26.531 (26/98) 2.85E-05
Serine/threonine-protein kinase cot (COT)
PF00069
23.552 (61/259) 3.28E-05
NDR1 protein kinase (STK38)
PF00069 ; 
PF00433
21.622 (56/259) 3.48E-05
Homeodomain-interacting protein kinase 1 (HIPK1)
PF00069
25.373 (51/201) 3.96E-05
Anti-mullerian hormone II receptor (AMHR2)
PF00069
22.606 (85/376) 4.13E-05
NDR2 protein kinase (STK38L)
PF00069 ; 
PF00433
20.233 (52/257) 5.82E-05
Rhodopsin kinase GRK7 (GRK7)
PF00069 ; 
PF00615
24.444 (44/180) 9.00E-05
G protein-coupled receptor kinase 4 (GRK4)
PF00069 ; 
PF00615
19.903 (41/206) 1.05E-04
Wee1-like protein kinase (WEE1)
PF00069
27.007 (37/137) 1.07E-04
Glycogen synthase kinase-3 alpha (GSK-3A)
PF00069
26.108 (53/203) 1.14E-04
Large tumor suppressor homolog 2 (LATS2)
PF00069 ; 
PF00433
20.635 (65/315) 1.31E-04
Homeodomain interacting protein kinase 2 (HIPK2)
PF00069
24.878 (51/205) 1.98E-04
Dual specificity protein kinase TTK (MPS1)
PF00069
22.340 (42/188) 2.15E-04
Serine/threonine-protein kinase ULK4 (ULK4)
PF00069
22.378 (64/286) 2.29E-04
Myotonin-protein kinase (DMPK)
PF08826 ; 
PF00069
22.172 (49/221) 2.49E-04
Serine/threonine-protein kinase 40 (STK40)
PF00069
21.547 (39/181) 2.60E-04
Rho-associated protein kinase 2 (ROCK2)
PF00069 ; 
PF08912
23.113 (49/212) 4.19E-04
Cyclin-G-associated kinase (GAK)
PF00069 ; 
PF10409
22.308 (58/260) 8.68E-04
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)
PF00069
23.950 (57/238) 1.00E-03
CDC7-related kinase (CDC7)
PF00069
20.792 (63/303) 1.00E-03
Rho-associated protein kinase 1 (ROCK1)
PF00069 ; 
PF08912
22.326 (48/215) 1.00E-03
Eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4)
PF12745 ; 
PF00069 ; 
PF05773 ; 
PF13393
More >>
 22.672 (56/247) 2.00E-03
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)
PF00069
24.183 (37/153) 2.00E-03
Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2)
PF00069
22.439 (46/205) 2.00E-03
SCY1-like protein 2 (SCYL2)
PF00069
27.907 (36/129) 3.00E-03
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3)
PF01412 ; 
PF00169 ; 
PF00788 ; 
PF00620 ; 
PF07647
More >>
 36.364 (20/55) 3.00E-03
BMP-2-inducible protein kinase (BMP2K)
PF15282 ; 
PF00069
30.108 (28/93) 5.00E-03
  Click to Show/Hide the Information of Human Similarity Proteins
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
 Download Picture         KEGG Link      
KEGG Pathway Pathway ID Affiliated Target Pathway Map
Axon guidance hsa04360 Affiliated Target
  Class: Organismal Systems => Development and regeneration Pathway Hierarchy
Degree 8 Degree centrality 8.59E-04 Betweenness centrality 4.48E-05
Closeness centrality 2.12E-01 Radiality 1.37E+01 Clustering coefficient 1.79E-01
Neighborhood connectivity 2.58E+01 Topological coefficient 1.58E-01 Eccentricity 12
Download Click to Download the Full PPI Network of This Target

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