Target Information
| Target General Information | Top | |||||
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| Target ID |
T28343
(Former ID: TTDR01341)
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| Target Name |
E2F3 messenger RNA (E2F3 mRNA)
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| Synonyms |
Transcription factor E2F3 (mRNA); KIAA0075 (mRNA); E2F-3 (mRNA)
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| Gene Name |
E2F3
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters. Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| Sequence |
MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGFAAAAAAAAAPGAYIQI
LTTNTSTTSCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALG RGGSGGGGGPPAKRRLELGESGHQYLSDGLKTPKGKGRAALRSPDSPKTPKSPSEKTRYD TSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQKRRIYDITNVLEGIHLIKKKSKNNVQ WMGCSLSEDGGMLAQCQGLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVT YQDIRKISGLKDQTVIVVKAPPETRLEVPDSIESLQIHLASTQGPIEVYLCPEETETHSP MKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEG PFVNLLPPLLQEDYLLSLGEEEGISDLFDAYDLEKLPLVEDFMCS Click to Show/Hide
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| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| References | Top | |||||
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| REF 1 | US patent application no. 6,165,791, Antisense inhibition of E2F transcription factor 3 expression. | |||||
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