Target Information
| Target General Information | Top | |||||
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| Target ID |
T24800
(Former ID: TTDR01434)
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| Target Name |
RANK messenger RNA (RANK mRNA)
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| Synonyms |
Tumor necrosis factor receptor superfamily member 11A (mRNA); Receptor activator of NF-KB (mRNA); RANK (mRNA); Osteoclast differentiation factor receptor (mRNA); ODFR (mRNA); CD265 (mRNA)
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| Gene Name |
TNFRSF11A
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Involved in the regulation of interactions between T-cells and dendritic cells. Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| Sequence |
MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKC
TTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHW SQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGK RVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGK ALTANLWHWINEACGRLSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMC YPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQL LFLTEPGSKSTPPFSEPLEVGENDSLSQCFTGTQSTVGSESCNCTEPLCRTDWTPMSSEN YLQKEVDSGHCPHWAASPSPNWADVCTGCRNPPGEDCEPLVGSPKRGPLPQCAYGMGLPP EEEASRTEARDQPEDGADGRLPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVM NFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLRE PEKASRPVQEQGGAKA Click to Show/Hide
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| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Target Affiliated Biological Pathways | Top | |||||
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| KEGG Pathway | [+] 5 KEGG Pathways | + | ||||
| 1 | Cytokine-cytokine receptor interaction | |||||
| 2 | NF-kappa B signaling pathway | |||||
| 3 | Osteoclast differentiation | |||||
| 4 | Prolactin signaling pathway | |||||
| 5 | Rheumatoid arthritis | |||||
| NetPath Pathway | [+] 2 NetPath Pathways | + | ||||
| 1 | IL2 Signaling Pathway | |||||
| 2 | RANKL Signaling Pathway | |||||
| Reactome | [+] 2 Reactome Pathways | + | ||||
| 1 | TNFR2 non-canonical NF-kB pathway | |||||
| 2 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | |||||
| WikiPathways | [+] 2 WikiPathways | + | ||||
| 1 | RANKL/RANK Signaling Pathway | |||||
| 2 | Osteoclast Signaling | |||||
| References | Top | |||||
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| REF 1 | US patent application no. 6,171,860, Antisense inhibition of rank expression. | |||||
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