Target Information
Target General Information | Top | |||||
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Target ID |
T07893
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Target Name |
Polyamine transport (Poly trans)
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Gene Name |
NOUNIPROTAC
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Target Type |
Clinical trial target
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[1] | ||||
Disease | [+] 1 Target-related Diseases | + | ||||
1 | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | |||||
UniProt ID |
Drugs and Modes of Action | Top | |||||
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Clinical Trial Drug(s) | [+] 1 Clinical Trial Drugs | + | ||||
1 | AMXT1501 | Drug Info | Phase 1 | Solid tumour/cancer | [2] | |
Mode of Action | [+] 1 Modes of Action | + | ||||
Inhibitor | [+] 1 Inhibitor drugs | + | ||||
1 | AMXT1501 | Drug Info | [1] |
References | Top | |||||
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REF 1 | AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport. Int J Cancer. 2013 Sep 15;133(6):1323-33. | |||||
REF 2 | ClinicalTrials.gov (NCT03536728) Oral AMXT 1501 Dicaprate in Combination With DFMO. U.S. National Institutes of Health. |
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