Target Information
| Target General Information | Top | |||||
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| Target ID |
T06365
(Former ID: TTDI02368)
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| Target Name |
Alanine glyoxylate aminotransferase (AGXT)
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| Synonyms |
Serine--pyruvate aminotransferase; SPAT; Alanine--glyoxylate aminotransferase; AGT1; AGT
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| Gene Name |
AGXT
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| Target Type |
Literature-reported target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Inborn carbohydrate metabolism error [ICD-11: 5C51] | |||||
| Function |
Catalyzes L-alanine and glyoxylate to pyruvate and glycine. Participates in alanine and aspartate metabolism and glycine, serine and threonine metabolism.
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| BioChemical Class |
Transaminase
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| UniProt ID | ||||||
| EC Number |
EC 2.6.1.51
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| Sequence |
MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI
KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR IGLLGCNATRENVDRVTEALRAALQHCPKKKL Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Discontinued Drug(s) | [+] 1 Discontinued Drugs | + | ||||
| 1 | AMT-030 | Drug Info | Terminated | Hyperoxaluria | [2] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Modulator | [+] 1 Modulator drugs | + | ||||
| 1 | AMT-030 | Drug Info | [1] | |||
| Target Affiliated Biological Pathways | Top | |||||
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| KEGG Pathway | [+] 7 KEGG Pathways | + | ||||
| 1 | Alanine, aspartate and glutamate metabolism | |||||
| 2 | Glycine, serine and threonine metabolism | |||||
| 3 | Glyoxylate and dicarboxylate metabolism | |||||
| 4 | Metabolic pathways | |||||
| 5 | Biosynthesis of antibiotics | |||||
| 6 | Carbon metabolism | |||||
| 7 | Peroxisome | |||||
| Pathwhiz Pathway | [+] 2 Pathwhiz Pathways | + | ||||
| 1 | Alanine Metabolism | |||||
| 2 | Glycine and Serine Metabolism | |||||
| WikiPathways | [+] 2 WikiPathways | + | ||||
| 1 | Metabolism of amino acids and derivatives | |||||
| 2 | Alanine and aspartate metabolism | |||||
| References | Top | |||||
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| REF 1 | Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med. 2011 Dec 22;365(25):2357-65. | |||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024084) | |||||
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