Target Information

Target General Information

Target ID

T03871 (Former ID: TTDR01356)

Target Name

H-ras messenger RNA (HRAS mRNA)

Synonyms

p21ras (mRNA); cHras (mRNA); c-H-ras (mRNA); Transforming protein p21 (mRNA); HaRas (mRNA); Ha-Ras (mRNA); H-Ras-1 (mRNA); GTPase HRas, Nterminally processed (mRNA); GTPase HRas (mRNA)

Click to Show/Hide

Gene Name

HRAS

Target Type

Discontinued target

[1]

Disease

[+] 1 Target-related Diseases

Solid tumour/cancer [ICD-11: 2A00-2F9Z]

Function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Involved in the activation of Ras protein signal transduction.

Click to Show/Hide

BioChemical Class

mRNA target

UniProt ID

RASH_HUMAN

Sequence

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS

Click to Show/Hide

Cell-based Target Expression Variations

Top

Cell-based Target Expression Variations

Cell-based Target Expression Variations Info

Target Affiliated Biological Pathways		Top
KEGG Pathway	[+] 52 KEGG Pathways	+
1	MAPK signaling pathway
2	ErbB signaling pathway
3	Ras signaling pathway
4	Rap1 signaling pathway
5	Chemokine signaling pathway
6	FoxO signaling pathway
7	Sphingolipid signaling pathway
8	Endocytosis
9	PI3K-Akt signaling pathway
10	Axon guidance
11	VEGF signaling pathway
12	Focal adhesion
13	Tight junction
14	Gap junction
15	Signaling pathways regulating pluripotency of stem cells
16	Natural killer cell mediated cytotoxicity
17	T cell receptor signaling pathway
18	B cell receptor signaling pathway
19	Fc epsilon RI signaling pathway
20	Long-term potentiation
21	Neurotrophin signaling pathway
22	Cholinergic synapse
23	Serotonergic synapse
24	Long-term depression
25	Regulation of actin cytoskeleton
26	Insulin signaling pathway
27	GnRH signaling pathway
28	Estrogen signaling pathway
29	Melanogenesis
30	Prolactin signaling pathway
31	Thyroid hormone signaling pathway
32	Oxytocin signaling pathway
33	Alcoholism
34	Hepatitis C
35	Hepatitis B
36	HTLV-I infection
37	Pathways in cancer
38	Viral carcinogenesis
39	Proteoglycans in cancer
40	MicroRNAs in cancer
41	Renal cell carcinoma
42	Endometrial cancer
43	Glioma
44	Prostate cancer
45	Thyroid cancer
46	Melanoma
47	Bladder cancer
48	Chronic myeloid leukemia
49	Acute myeloid leukemia
50	Non-small cell lung cancer
51	Central carbon metabolism in cancer
52	Choline metabolism in cancer
NetPath Pathway	[+] 1 NetPath Pathways	+
1	TCR Signaling Pathway
Panther Pathway	[+] 11 Panther Pathways	+
1	Angiogenesis
2	B cell activation
3	EGF receptor signaling pathway
4	FGF signaling pathway
5	Integrin signalling pathway
6	PDGF signaling pathway
7	TGF-beta signaling pathway
8	T cell activation
9	VEGF signaling pathway
10	Ras Pathway
11	p53 pathway feedback loops 2
Pathwhiz Pathway	[+] 4 Pathwhiz Pathways	+
1	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
2	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
3	Fc Epsilon Receptor I Signaling in Mast Cells
4	Insulin Signalling
PID Pathway	[+] 40 PID Pathways	+
1	Fc-epsilon receptor I signaling in mast cells
2	Endothelins
3	BCR signaling pathway
4	LPA receptor mediated events
5	Insulin Pathway
6	GMCSF-mediated signaling events
7	TCR signaling in na&#xef
8
9	Plasma membrane estrogen receptor signaling
10	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
11	EPHB forward signaling
12	CDC42 signaling events
13	Signaling events regulated by Ret tyrosine kinase
14	TCR signaling in na&#xef
15
16	SHP2 signaling
17	mTOR signaling pathway
18	IL2-mediated signaling events
19	IGF1 pathway
20	EGF receptor (ErbB1) signaling pathway
21	Ras signaling in the CD4+ TCR pathway
22	EGFR-dependent Endothelin signaling events
23	Class I PI3K signaling events
24	Posttranslational regulation of adherens junction stability and dissassembly
25	ErbB1 downstream signaling
26	ErbB2/ErbB3 signaling events
27	PDGFR-beta signaling pathway
28	Neurotrophic factor-mediated Trk receptor signaling
29	C-MYB transcription factor network
30	Nongenotropic Androgen signaling
31	Internalization of ErbB1
32	CXCR3-mediated signaling events
33	Signaling events mediated by Stem cell factor receptor (c-Kit)
34	EPO signaling pathway
35	a6b1 and a6b4 Integrin signaling
36	Syndecan-2-mediated signaling events
37	Regulation of Ras family activation
38	Trk receptor signaling mediated by the MAPK pathway
39	Trk receptor signaling mediated by PI3K and PLC-gamma
40	Downstream signaling in na&#xef
Reactome	[+] 34 Reactome Pathways	+
1	SOS-mediated signalling
2	Activation of RAS in B cells
3	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
4	SHC1 events in ERBB2 signaling
5	SHC1 events in ERBB4 signaling
6	p38MAPK events
7	GRB2 events in EGFR signaling
8	SHC1 events in EGFR signaling
9	GRB2 events in ERBB2 signaling
10	Tie2 Signaling
11	EGFR Transactivation by Gastrin
12	DAP12 signaling
13	SHC-related events triggered by IGF1R
14	FCERI mediated MAPK activation
15	NCAM signaling for neurite out-growth
16	EPHB-mediated forward signaling
17	Ras activation uopn Ca2+ infux through NMDA receptor
18	VEGFR2 mediated cell proliferation
19	CD209 (DC-SIGN) signaling
20	Constitutive Signaling by EGFRvIII
21	SHC-mediated cascade:FGFR1
22	FRS-mediated FGFR1 signaling
23	SHC-mediated cascade:FGFR2
24	FRS-mediated FGFR2 signaling
25	SHC-mediated cascade:FGFR3
26	FRS-mediated FGFR3 signaling
27	FRS-mediated FGFR4 signaling
28	SHC-mediated cascade:FGFR4
29	Regulation of RAS by GAPs
30	RAF activation
31	RAF/MAP kinase cascade
32	MAP2K and MAPK activation
33	Negative regulation of MAPK pathway
34	Insulin receptor signalling cascade
WikiPathways	[+] 51 WikiPathways	+
1	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
2	DNA Damage Response (only ATM dependent)
3	TCR Signaling Pathway
4	ErbB Signaling Pathway
5	Senescence and Autophagy in Cancer
6	TGF Beta Signaling Pathway
7	IL-2 Signaling Pathway
8	Insulin Signaling
9	EGF/EGFR Signaling Pathway
10	MAPK Cascade
11	p38 MAPK Signaling Pathway
12	G Protein Signaling Pathways
13	Signaling of Hepatocyte Growth Factor Receptor
14	Kit receptor signaling pathway
15	Extracellular vesicle-mediated signaling in recipient cells
16	IL-3 Signaling Pathway
17	Bladder Cancer
18	Signaling by ERBB4
19	Signaling by ERBB2
20	Fc epsilon receptor (FCERI) signaling
21	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
22	Signaling by the B Cell Receptor (BCR)
23	RAF/MAP kinase cascade
24	Interleukin-2 signaling
25	Signaling by SCF-KIT
26	DAP12 interactions
27	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
28	Gastrin-CREB signalling pathway via PKC and MAPK
29	Nanoparticle-mediated activation of receptor signaling
30	JAK/STAT
31	Aryl Hydrocarbon Receptor
32	PDGF Pathway
33	Alpha 6 Beta 4 signaling pathway
34	BDNF signaling pathway
35	Oncostatin M Signaling Pathway
36	Interleukin-11 Signaling Pathway
37	TNF alpha Signaling Pathway
38	B Cell Receptor Signaling Pathway
39	RalA downstream regulated genes
40	Prostate Cancer
41	Signaling Pathways in Glioblastoma
42	Leptin signaling pathway
43	Signaling by PDGF
44	Signaling by Insulin receptor
45	Signaling by FGFR
46	Signaling by EGFR
47	NGF signalling via TRKA from the plasma membrane
48	NCAM signaling for neurite out-growth
49	Integrin-mediated Cell Adhesion
50	Interleukin-3, 5 and GM-CSF signaling
51	Cell surface interactions at the vascular wall

References

Top

REF 1

A phase I trial of ISIS 2503, an antisense inhibitor of H-ras, in combination with gemcitabine in patients with advanced cancer. Clin Cancer Res. 2003 Jan;9(1):115-23.

REF 2

US patent application no. 7,425,545, Modulation of C-reactive protein expression.

REF 3

US patent application no. 5,965,722, Antisense inhibition of ras gene with chimeric and alternating oligonucleotides.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Prof. Feng ZHU

Prof. Yuzong CHEN