Target Information

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Target General Information
Different Human System Profiles of Target
Cell-based Target Expression Variations
Target-Related Models and Studies
References
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
Protein Name Pfam ID Percentage of Identity (%) E value
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5)
PF01209
29.213 (26/89) 1.20E-04
Trimethylguanosine synthase (TGS1)
PF09445
35.593 (21/59) 1.21E-04
Ubiquinone biosynthesis O-methyltransferase, mitochondrial (COQ3)
PF13489
29.703 (30/101) 3.00E-03

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