Target Validation Information
TTD ID T98459
Target Name G2/mitotic-specific cyclin B1 (CCNB1)
Type of Target
Patented-recorded
Drug Potency against Target 3,4-bis(indol-3-yl)maleimide derivative Drug Info IC50 = 4500 nM [3]
AZAKENPAULLONE Drug Info IC50 = 2000 nM [1]
Bisindolylmaleimide-I Drug Info IC50 = 19000 nM [3]
KENPAULLONE Drug Info IC50 = 400 nM [2]
RO-316233 Drug Info IC50 = 18000 nM [3]
Thieno analogue of kenpaullone Drug Info IC50 = 600 nM [1]
References
REF 1 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.
REF 2 Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay. Eur J Med Chem. 2010 Sep;45(9):4316-30.
REF 3 Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure. Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.