Target Validation Information
TTD ID	T97713
Target Name	Amidophosphoribosyltransferase (PPAT)
Type of Target	Successful
Drug Potency against Target	Azathioprine	Drug Info	IC50 = 500 nM	[4]
	Mycophenolic bis(sulfonamide)	Drug Info	Ki = 18200 nM	[2]
	Mycophenolic hydroxamic acid	Drug Info	IC50 = 350 nM	[3]
	Tiazofurin adenine dinucleotide	Drug Info	Ki = 100 nM	[1]
References
REF 1	Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. J Med Chem. 2007 Dec 27;50(26):6685-91.
REF 2	Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9.
REF 3	Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycoph... Bioorg Med Chem. 2010 Nov 15;18(22):8106-11.
REF 4	AMPA receptor antagonists as potential anticonvulsant drugs. Curr Top Med Chem. 2005;5(1):31-42.

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