| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T95594 | ||||
| Target Name | PI3K p110 beta messenger RNA (PIK3CB mRNA) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | 3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol | Drug Info | IC50 = 16 nM | [2] | |
| Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate | Drug Info | IC50 = 6000 nM | [1] | ||
| LY-292223 | Drug Info | IC50 = 14000 nM | [1] | ||
| References | |||||
| REF 1 | LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. | ||||
| REF 2 | Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem. 2007 Sep 1;15(17):5837-44. | ||||
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