Target Validation Information
TTD ID	T95139
Target Name	Cysteine protease (CYP)
Type of Target	Successful
Drug Potency against Target	ALLICIN	Drug Info	Ki = 5310 nM	[2]
	K-777	Drug Info	IC50 = 7 nM	[1]
	S-benzyl phenylmethanesulfinothioate	Drug Info	Ki = 2310 nM	[2]
	S-hexyl hexane-1-sulfinothioate	Drug Info	Ki = 1000 nM	[2]
	S-isopentyl 3-methylbutane-1-sulfinothioate	Drug Info	Ki = 360 nM	[2]
	S-propyl propane-1-sulfinothioate	Drug Info	Ki = 4440 nM	[2]
References
REF 1	Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21.
REF 2	Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3.

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