Target Validation Information
TTD ID	T93344
Target Name	Squalene monooxygenase (SQLE)
Type of Target	Successful
Drug Potency against Target	1(beta)-O-galloylpedunculagin	Drug Info	IC50 = 7000 nM	[1]
	1,2,3,4,6-penta-O-galloyl-beta-D-glucose	Drug Info	IC50 = 470 nM	[1]
	1,2,6-tri-O-galloyl-beta-D-glucose	Drug Info	IC50 = 630 nM	[1]
	Chebulinic acid	Drug Info	IC50 = 12000 nM	[1]
	CORILAGIN	Drug Info	IC50 = 4000 nM	[1]
	ELLAGIC ACID	Drug Info	IC50 = 2000 nM	[1]
	Epigallocatechin gallate	Drug Info	IC50 = 690 nM	[1]
	ETHYLGALLATE	Drug Info	IC50 = 4200 nM	[1]
	EUGENIIN	Drug Info	IC50 = 1600 nM	[1]
	FUROSIN	Drug Info	IC50 = 10000 nM	[1]
	GERANIIN	Drug Info	IC50 = 4100 nM	[1]
	Mallotinic acid	Drug Info	IC50 = 8000 nM	[1]
	Mallotusinic acid	Drug Info	IC50 = 8000 nM	[1]
	N-cetylgallate	Drug Info	IC50 = 590 nM	[1]
	N-dodecylgallate	Drug Info	IC50 = 61 nM	[1]
	OCTYL_GALLATE	Drug Info	IC50 = 830 nM	[1]
	Pedunculagin	Drug Info	IC50 = 2000 nM	[1]
	Procyanidin B-2 3,3'-di-O-gallate	Drug Info	IC50 = 540 nM	[1]
	Sanguiin H-6	Drug Info	IC50 = 12000 nM	[1]
	THEASINENSIN A	Drug Info	IC50 = 130 nM	[1]
	Trisnorsqualene alcohol	Drug Info	IC50 = 4000 nM	[1]
	Trisnorsqualene cyclopropylamine	Drug Info	IC50 = 2000 nM	[1]
	Trisnorsqualene difluoromethylidene	Drug Info	IC50 = 5400 nM	[1]
References
REF 1	Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4.

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